rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The variant in rs3817198 has a prognostic effect particularly in the subgroup of patients with triple-negative BC, suggesting a possible link with immunomodulation and BC.
|
28757652 |
2017 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The objective of this study was to investigate whether the genetic polymorphism rs12665607 of ESR1, rs10995190 of ZNF365, rs3817198 of LSP1 and rs17001868 of SGSM3/MKL1 are associated with the development of breast cancer (BC) in the Chinese women.
|
27432265 |
2017 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These findings indicate the LSP1 rs3817198 T > C polymorphism is associated with increased risk of breast cancer, especially in Caucasian and Asian populations.
|
27590509 |
2016 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Subjects carrying an allele of rs2981582 had reduced breast cancer risk (GA vs GG: OR=0.444, 95% CI=0.262-0.752; AA vs GG: OR=0.579, 95% CI=0.342-0.983). rs3803662 and rs3817198 SNPs did not significantly differ between cases and controls (P=0.408 and 0.116, respectively).
|
26911390 |
2016 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (P int) in a meta-analysis of genome-wide gene-environment interaction studies with MHT use on risk of breast cancer, 2541 SNPs in candidate genes (AKR1C4, CYP1A1-CYP1A2, CYP1B1, ESR2, PPARG, PRL, SULT1A1-SULT1A2 and TNF) and ten SNPs (AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, ZNF365-rs10995190, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, 12q24-rs1265507, TMEM184B-rs7289126, and SGSM3-rs17001868) associated with mammographic density in genome-wide studies.
|
26275715 |
2015 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, we show that there is little overlap between the breast cancer risk single nucleotide polymorphisms (SNPs) identified so far and the SNPs associated with breast cancer prognosis, with the possible exceptions of LSP1-rs3817198 and TNRC9-rs3803662.
|
25611573 |
2015 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings demonstrate a novel pleiotropic association between the breast cancer LSP1 risk region marked by variant rs3817198 and lung cancer risk.
|
24681604 |
2014 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, LSP1-rs3817198 and RAD51L1-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association.
|
22454379 |
2012 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
But no significant association was observed for all compari</span>son models between LSP1 rs3817198T>C polymorphism and breast cancer risk in hospital-based and people-based studies.
|
21127985 |
2011 |
rs3817198
|
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres.
|
19656774 |
2009 |