Source: BEFREE

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes. 30710592

2019

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE A specific genetic variant, rs13266634 (c.973C>T; p.ARG325TRP) in zinc transporter SLC30A8/ZnT8, is associated with protection against Type-2 Diabetes, suggesting it may be actionable for predicting and preventing POHG. 31220282

2019

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The current study demonstrated a modest but significant effect of SLC30A8 (rs13266634) polymorphisms on T2D predisposition. 31823921

2019

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes. 29430817

2018

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044). 30142362

2018

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE <b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR. 30319545

2018

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM. 27899481

2017

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population. 28067832

2017

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). 28738793

2017

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D). 28965566

2017

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The solute carrier family 30 member 8 gene (<i>SLC30A8</i>) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in <i>SLC30A8</i> is associated with an increased risk of type 2 diabetes (T2D). 29093761

2017

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies. 26832344

2016

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes. 27003436

2016

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D. 27310578

2016

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE We assessed the interaction between type 2 diabetes-associated SLC30A8 rs13266634 and gestational weight gain on 1-5 years of postpartum glycemic changes in 1,071 women with prior GDM in a longitudinal study. 27600066

2016

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE SLC30A8 encodes a zinc transporter in the beta cell; individuals with a common missense variant (rs13266634; R325W) in SLC30A8 demonstrate a lower early insulin response to glucose and an increased risk of type 2 diabetes. 25348609

2015

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D. 25839936

2015

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations. 25875676

2015

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations. 26214053

2015

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds. 24306209

2014

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Thus, the present study aimed to investigate the association between rs13266634 polymorphism and T2DM in Fars province, Southern Iran and compare the results with other populations. 24449369

2014

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes. 24471563

2014

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. 24584071

2014

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Gene-environment interaction analysis showed a significant interaction between rs13266634 in SLC30A8 gene and age on T2DM risk (P<0.0001). 24736664

2014

dbSNP: rs13266634
rs13266634
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05]. 24993573

2014