Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab. 23182985

2013

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335

2011

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335

2011

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. 21398618

2011

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. 21228335

2011

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. 20921462

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. 20921465

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. 20921462

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. 20921462

2010

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. 19679400

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. 19679400

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells. 19881948

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. 19679400

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. 19114683

2009

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. 18316791

2008

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. 18316791

2008

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
T 0.700 CausalMutation CLINVAR Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. 18316791

2008

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
A 0.700 CausalMutation CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717

2006

dbSNP: rs121913529
rs121913529
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
G 0.700 CausalMutation CLINVAR KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 16618717

2006