|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
Additionally, we show that the interaction of 8 NIPs is compromised with the 3 main CD associated NOD2 mutants (R702W, G908R and 1007fs).
|
27812135 |
2016 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
|
24790089 |
2014 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.
|
24960071 |
2014 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
GWASDB |
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.
|
17804789 |
2007 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
GWASDB |
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
|
17684544 |
2007 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
We performed a limited DNA sequence analysis of the CARD15 gene in 89 patients with Crohn's disease (CD), 19 patients with ulcerative colitis (UC), and three patients with indeterminate colitis (IC), who were heterozygous carriers of one of the common CARD15 mutations [c.2104C>T (p.R702W), c.2722G>C (p.G908R), or c.3019_3020insC (p.Leu1007fsX1008)], the c.2462+10A>C variant, or of a new amino acid substitution in the 3'-end of exon 4.
|
16485124 |
2006 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
A higher frequency of CARD15 mutations was found in AJ patients from multiplex families with CD from Central (44.0%) versus Eastern (24.0%) Europe, especially for G908R and 1007fs, and in SOJ patients (34.5%) compared with AJ (10.1%) or SOJ (5.4%) controls.
|
15024686 |
2004 |
|
rs2066845
|
|
Crohn Disease
|
|
1.000 |
GeneticVariation
|
UNIPROT |
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
|
11385576 |
2001 |