|
rs3849942
|
|
Amyotrophic Lateral Sclerosis
|
A |
0.870 |
GeneticVariation
|
GWASDB |
Eight genomic regions provided evidence of association with ALS, including 9p21.2 (rs3849942, odds ratio [OR] = 1.21; p = 4.41 × 10(-7)), 17p11.2 (rs7477, OR = 1.30; p = 2.89 × 10(-7)), and 19p13 (rs12608932, OR = 1.37, p = 1.29 × 10(-7)).
|
22959728 |
2013 |
|
rs3849942
|
|
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association testing was performed first using all samples, and then restricting the analysis to samples not carrying the mutation. rs3849942 and rs903603 were strongly associated with ALS when all samples were included (rs3849942, p = [3 × 2] × 10(-6), rank 7/442,057; rs903603, p = [7 × 6] × 10(-8), rank 2/442,057).
|
23587638 |
2013 |
|
rs3849942
|
|
Amyotrophic Lateral Sclerosis
|
A |
0.870 |
GeneticVariation
|
GWASDB |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
|
rs3849942
|
|
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
|
rs3849942
|
|
Amyotrophic Lateral Sclerosis
|
|
0.870 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs2814707
|
|
Amyotrophic Lateral Sclerosis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs2814707
|
|
Amyotrophic Lateral Sclerosis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
|
20801718 |
2010 |
|
rs2814707
|
|
Amyotrophic Lateral Sclerosis
|
|
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs10122902
|
|
Amyotrophic Lateral Sclerosis
|
|
0.800 |
GeneticVariation
|
GWASDB |
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
|
20801717 |
2010 |
|
rs10757665
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs10812611
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs10967976
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs12349820
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs1565948
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs2282240
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs2282241
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs60242496
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs774357
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs774359
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs774359
|
|
Amyotrophic Lateral Sclerosis
|
|
0.700 |
GeneticVariation
|
GWASDB |
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
|
20801718 |
2010 |