Source: CURATED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 57 0.367 0.923 9.2E-29 1.000 strong 0.956 34 160 1992 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 56 0.379 0.846 2.4E-25 1.000 strong 0.951 30 174 1994 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 113 0.324 0.962 1.00 1.000 None 0.967 14 3 1983 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 98 0.292 0.923 1.00 1.000 None 0.985 9 8 2001 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 232 0.236 0.962 0.53 1.000 None 0.973 6 9 1982 2020
Entrez Id: 580
Gene Symbol: BARD1
BARD1 		Q99728 BRCA1 associated RING domain 1 15 0.597 0.538 1.4E-24 1.000 limited 0.896 0 63 1996 2020
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 83 0.328 0.923 6.0E-03 0.800 None 0.970 40 0 1987 2020
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		O96017 checkpoint kinase 2 Kinase 47 0.460 0.808 1.2E-24 0.800 None 0.963 7 139 2001 2019
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		Q86YC2 partner and localizer of BRCA2 33 0.485 0.769 3.0E-19 0.800 None 0.970 6 221 2006 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 182 0.305 0.923 0.26 0.800 strong 0.956 4 1 1997 2020
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1 		Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 21 0.507 0.731 6.2E-17 0.800 None 0.951 4 99 2001 2020
Entrez Id: 857
Gene Symbol: CAV1
CAV1 		Q03135 caveolin 1 Enzyme modulator 58 0.388 0.885 8.3E-03 0.800 None 0.977 4 1 1999 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 73 0.401 0.808 0.15 0.800 limited 1.000 4 5 1991 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 109 0.311 0.962 0.98 0.700 limited 0.993 3 1 1999 2020
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		P21802 fibroblast growth factor receptor 2 Kinase 93 0.380 0.808 1.00 0.700 None 0.942 3 11 1991 2020
Entrez Id: 2033
Gene Symbol: EP300
EP300 		Q09472 E1A binding protein p300 40 0.459 0.846 1.00 0.700 None 1.000 1 1 2004 2020
Entrez Id: 472
Gene Symbol: ATM
ATM 		Q13315 ATM serine/threonine kinase Kinase 72 0.374 0.885 5.6E-47 0.700 None 0.932 1 42 1996 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 164 0.320 0.923 7.9E-04 0.700 None 0.947 0 1 2005 2020
Entrez Id: 8438
Gene Symbol: RAD54L
RAD54L 		Q92698 RAD54 like 20 0.633 0.423 2.4E-15 0.620 None 0.500 0 1 2017 2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 120 0.378 0.885 8.0E-02 0.600 None 0.906 4 0 1986 2018
Entrez Id: 841
Gene Symbol: CASP8
CASP8 		Q14790 caspase 8 Enzyme 58 0.404 0.923 3.7E-06 0.600 None 0.979 4 0 2004 2019
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		Q92731 estrogen receptor 2 Nuclear receptor 73 0.400 0.923 4.5E-08 0.600 None 0.970 3 0 1996 2020
Entrez Id: 5925
Gene Symbol: RB1
RB1 		P06400 RB transcriptional corepressor 1 Nucleic acid binding 65 0.444 0.885 1.00 0.600 None 0.958 3 0 1992 2020
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1 		P11362 fibroblast growth factor receptor 1 Kinase 87 0.362 0.885 1.00 0.600 None 0.976 2 0 1999 2020
Entrez Id: 2321
Gene Symbol: FLT1
FLT1 		P17948 fms related receptor tyrosine kinase 1 Kinase 39 0.419 0.846 1.00 0.600 None 1.000 2 0 1999 2019