Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.500 None 0.867 59 0 1997 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.400 None 0.945 710 7 1990 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.400 None 0.976 205 3 1988 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.400 None 0.969 128 1 1984 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 576 0.367 0.923 9.2E-29 0.400 None 0.975 80 0 1996 2020
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		P10415 BCL2 apoptosis regulator Signaling 1294 0.291 0.885 0.56 0.400 None 0.911 78 0 1994 2018
Entrez Id: 595
Gene Symbol: CCND1
CCND1 		P24385 cyclin D1 Enzyme modulator 748 0.344 0.923 0.89 0.400 None 0.962 75 0 1990 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 972 0.324 0.962 1.00 0.400 None 0.957 68 4 1982 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1043 0.314 0.962 1.00 0.400 None 0.982 57 0 1994 2019
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 457 0.378 0.885 8.0E-02 0.400 None 0.962 51 2 1983 2019
Entrez Id: 4233
Gene Symbol: MET
MET 		P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 501 0.380 0.846 0.97 0.400 None 0.958 47 0 1991 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 396 0.401 0.808 0.15 0.400 None 1.000 44 0 1994 2019
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM 		P16422 epithelial cell adhesion molecule 259 0.451 0.885 1.3E-07 0.400 None 1.000 37 0 1989 2019
Entrez Id: 2272
Gene Symbol: FHIT
FHIT 		P49789 fragile histidine triad diadenosine triphosphatase 281 0.444 0.846 5.7E-03 0.400 None 0.909 32 0 1996 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC 		P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 747 0.344 0.923 1.00 0.400 None 0.970 32 0 1989 2019
Entrez Id: 5241
Gene Symbol: PGR
PGR 		P06401 progesterone receptor Nuclear receptor 341 0.426 0.885 5.1E-02 0.400 None 0.970 32 0 1989 2018
Entrez Id: 8626
Gene Symbol: TP63
TP63 		Q9H3D4 tumor protein p63 Transcription factor 553 0.362 0.769 1.00 0.400 None 1.000 29 1 2000 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		P08183 ATP binding cassette subfamily B member 1 Transporter 839 0.344 0.885 1.3E-05 0.400 None 0.966 28 1 1989 2015
Entrez Id: 7428
Gene Symbol: VHL
VHL 		P40337 von Hippel-Lindau tumor suppressor Enzyme 239 0.443 0.846 8.0E-02 0.400 None 1.000 23 0 1994 2019
Entrez Id: 2625
Gene Symbol: GATA3
GATA3 		P23771 GATA binding protein 3 367 0.415 0.846 0.90 0.400 None 1.000 22 0 2005 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		P01137 transforming growth factor beta 1 Signaling 1334 0.287 0.962 3.7E-02 0.400 None 1.000 22 0 1990 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 953 0.327 0.923 0.98 0.400 None 0.882 16 0 2001 2019
Entrez Id: 1019
Gene Symbol: CDK4
CDK4 		P11802 cyclin dependent kinase 4 Kinase 386 0.412 0.808 6.3E-02 0.400 None 1.000 13 0 1996 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1 		P02751 fibronectin 1 Signaling 647 0.365 0.962 1.4E-03 0.400 None 1.000 12 1 1992 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		P40763 signal transducer and activator of transcription 3 Nucleic acid binding 999 0.320 0.923 1.00 0.400 None 1.000 10 0 2005 2019