Source: ALL
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 1213 0.320 0.923 7.9E-04 0.500 None 0.983 117 12 1990 2019
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 703 0.373 0.962 1.00 0.900 None 0.982 109 15 1990 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1228 0.319 0.846 1.00 0.500 None 0.978 93 11 2002 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2494 0.236 0.962 0.53 0.700 None 0.989 89 68 1991 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1368 0.303 0.885 1.00 0.700 None 0.985 65 7 1997 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 526 0.399 0.808 3.4E-05 0.400 None 1.000 61 0 1997 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1234 0.314 0.962 1.00 0.400 None 1.000 43 0 1999 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1394 0.295 0.885 0.37 0.500 None 0.976 42 2 2003 2019
Entrez Id: 7298
Gene Symbol: TYMS
TYMS 		P04818 thymidylate synthetase Enzyme 406 0.425 0.846 0.72 0.600 None 1.000 37 0 1998 2015
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 490 0.406 0.808 0.90 0.400 None 1.000 31 0 1996 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1511 0.292 0.923 1.00 0.490 None 1.000 24 32 2004 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		P15692 vascular endothelial growth factor A Signaling 1899 0.266 0.923 2.4E-05 0.100 None 0.957 23 1 2002 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 985 0.337 0.885 3.2E-10 0.400 None 1.000 22 1 2002 2014
Entrez Id: 1806
Gene Symbol: DPYD
DPYD 		Q12882 dihydropyrimidine dehydrogenase Enzyme 249 0.493 0.846 3.4E-22 0.600 None 0.952 21 0 1999 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		Q13485 SMAD family member 4 Transcription factor 575 0.401 0.808 1.00 0.500 None 1.000 21 8 1996 2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS 		P01112 HRas proto-oncogene, GTPase Enzyme modulator 698 0.378 0.885 8.0E-02 0.200 None 1.000 20 8 1985 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		P14780 matrix metallopeptidase 9 Enzyme 1337 0.305 0.923 1.9E-17 0.300 None 1.000 20 0 2002 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 508 0.401 0.808 0.15 0.500 None 0.950 20 2 1999 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1314 0.300 0.885 0.39 0.200 None 1.000 19 2 2003 2016
Entrez Id: 100750225
Gene Symbol: PCAT1
PCAT1 		prostate cancer associated transcript 1 90 0.575 0.615 0.100 None 1.000 18 7 2007 2019
Entrez Id: 5462
Gene Symbol: POU5F1B
POU5F1B 		Q06416 POU class 5 homeobox 1B 36 0.670 0.346 2.9E-04 0.100 None 1.000 18 7 2007 2019
Entrez Id: 727677
Gene Symbol: CASC8
CASC8 		cancer susceptibility 8 35 0.670 0.462 0.100 None 1.000 18 7 2007 2019
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7 		O15105 SMAD family member 7 Transcription factor 269 0.470 0.769 0.55 0.410 None 1.000 17 7 2007 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 1021 0.333 0.923 0.84 0.700 None 1.000 17 1 1996 2016
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH 		Q9UIF7 mutY DNA glycosylase Enzyme 156 0.521 0.769 1.3E-18 0.100 None 1.000 17 0 2002 2013