Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 517 0.373 0.962 1.00 0.900 None 0.982 57 3 1990 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.700 None 0.989 44 2 1991 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.700 None 0.985 38 1 1997 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 826 0.333 0.923 0.84 0.700 None 1.000 6 0 1996 2016
Entrez Id: 7298
Gene Symbol: TYMS
TYMS 		P04818 thymidylate synthetase Enzyme 356 0.425 0.846 0.72 0.600 None 1.000 9 0 1998 2015
Entrez Id: 1806
Gene Symbol: DPYD
DPYD 		Q12882 dihydropyrimidine dehydrogenase Enzyme 170 0.493 0.846 3.4E-22 0.600 None 0.952 7 0 1999 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.500 None 0.983 56 0 1990 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.500 None 0.978 32 2 2002 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.500 None 0.976 25 1 2003 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		Q13485 SMAD family member 4 Transcription factor 377 0.401 0.808 1.00 0.500 None 1.000 7 0 1996 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 396 0.401 0.808 0.15 0.500 None 0.950 2 0 1999 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.490 None 1.000 5 0 2004 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		Q9NQB0 transcription factor 7 like 2 192 0.485 0.846 1.00 0.490 None 1.000 3 0 2002 2019
Entrez Id: 26585
Gene Symbol: GREM1
GREM1 		O60565 gremlin 1, DAN family BMP antagonist 145 0.508 0.808 0.47 0.430 None 1.000 3 0 2008 2020
Entrez Id: 894
Gene Symbol: CCND2
CCND2 		P30279 cyclin D2 Enzyme modulator 172 0.477 0.808 0.99 0.420 None 1.000 2 0 2011 2019
Entrez Id: 91653
Gene Symbol: BOC
BOC 		Q9BWV1 BOC cell adhesion associated, oncogene regulated 16 0.666 0.423 1.7E-07 0.410 None 1.000 1 0 2018 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 396 0.390 0.808 0.49 0.410 None 1.000 1 0 2006 2016
Entrez Id: 652
Gene Symbol: BMP4
BMP4 		P12644 bone morphogenetic protein 4 Signaling 325 0.422 0.808 0.96 0.410 None 1.000 1 0 2008 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1043 0.314 0.962 1.00 0.400 None 1.000 15 0 1999 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.400 None 1.000 14 0 1997 2019
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 404 0.406 0.808 0.90 0.400 None 1.000 11 0 1996 2019
Entrez Id: 3481
Gene Symbol: IGF2
IGF2 		P01344 insulin like growth factor 2 477 0.390 0.885 4.4E-02 0.400 None 1.000 8 0 1990 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2 		P10415 BCL2 apoptosis regulator Signaling 1294 0.291 0.885 0.56 0.400 None 1.000 5 0 1996 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		P01137 transforming growth factor beta 1 Signaling 1334 0.287 0.962 3.7E-02 0.400 None 1.000 3 0 1999 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 816 0.337 0.885 3.2E-10 0.400 None 1.000 2 1 2002 2014