Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.600 None 0.936 565 13 1991 2020
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.600 None 0.970 544 7 1989 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.400 None 0.973 512 10 1988 2020
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		P15692 vascular endothelial growth factor A Signaling 1737 0.266 0.923 2.4E-05 0.400 None 0.976 484 4 1994 2020
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		P14780 matrix metallopeptidase 9 Enzyme 1160 0.305 0.923 1.9E-17 0.600 None 0.991 428 4 1996 2020
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 681 0.362 0.923 1.8E-02 0.400 None 0.989 358 4 2000 2020
Entrez Id: 960
Gene Symbol: CD44
CD44 		P16070 CD44 molecule (Indian blood group) 664 0.363 0.962 2.4E-07 0.400 None 0.979 322 2 1990 2020
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.400 None 0.962 313 1 1996 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.400 None 0.976 290 3 2003 2020
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 953 0.327 0.923 0.98 0.100 None 0.986 282 2 2002 2020
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 826 0.333 0.923 0.84 0.600 None 0.983 281 2 1993 2020
Entrez Id: 4830
Gene Symbol: NME1
NME1 		P15531 NME/NM23 nucleoside diphosphate kinase 1 Kinase 317 0.443 0.808 3.2E-03 0.400 None 0.940 278 1 1989 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.100 None 0.932 278 6 2003 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		P40763 signal transducer and activator of transcription 3 Nucleic acid binding 999 0.320 0.923 1.00 0.400 None 0.996 246 0 2001 2020
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1087 0.320 0.885 1.4E-06 0.100 None 0.987 236 0 2004 2020
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB 		P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1077 0.322 0.885 1.00 0.100 None 0.987 231 1 2004 2020
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1105 0.319 0.885 1.00 0.100 None 0.987 230 1 2004 2020
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 972 0.324 0.962 1.00 0.400 None 0.962 228 3 1992 2020
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 1011 0.311 0.962 0.98 0.100 None 1.000 216 2 2002 2020
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12 		P48061 C-X-C motif chemokine ligand 12 593 0.379 0.846 0.12 0.400 None 0.995 210 1 2000 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.400 None 0.952 207 7 1991 2020
Entrez Id: 354
Gene Symbol: KLK3
KLK3 		P07288 kallikrein related peptidase 3 Enzyme 350 0.443 0.885 4.4E-06 0.100 None 0.974 193 1 1994 2020
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		P10451 secreted phosphoprotein 1 715 0.353 0.885 2.1E-06 0.400 None 0.989 189 0 1996 2020
Entrez Id: 29126
Gene Symbol: CD274
CD274 		Q9NZQ7 CD274 molecule Receptor 990 0.324 0.923 1.9E-02 0.100 None 0.954 173 0 2011 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.400 None 0.976 162 1 1997 2020