Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
Q06124 protein tyrosine phosphatase, non-receptor type 11 441 0.429 0.828 1.00 1.000 definitive 0.957 224 54 2001 2018
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
P04049 Raf-1 proto-oncogene, serine/threonine kinase 328 0.462 0.793 0.89 0.800 definitive 1.000 48 18 1991 2016
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
P01111 NRAS proto-oncogene, GTPase enzyme modulator 477 0.420 0.690 0.53 0.770 definitive 1.000 13 2 2004 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.700 1.000 50 12 2002 2016
Entrez Id: 6654
Gene Symbol: SOS1
SOS1
Q07889 SOS Ras/Rac guanine nucleotide exchange factor 1 enzyme modulator 183 0.536 0.655 1.00 0.700 0.933 47 22 1991 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.640 1.000 8 3 2007 2014
Entrez Id: 8036
Gene Symbol: SHOC2
SHOC2
Q9UQ13 SHOC2, leucine rich repeat scaffold protein 62 0.681 0.448 1.00 0.500 0.917 15 1 2009 2016
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
Q92963 Ras like without CAAX 1 enzyme modulator 113 0.619 0.621 0.15 0.470 1.000 13 13 2013 2017
Entrez Id: 5604
Gene Symbol: MAP2K1
MAP2K1
Q02750 mitogen-activated protein kinase kinase 1 330 0.459 0.759 0.91 0.340 1.000 5 0 2007 2014
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
P01112 HRas proto-oncogene, GTPase enzyme modulator 545 0.404 0.828 8.7E-02 0.330 1.000 4 0 2007 2009
Entrez Id: 5605
Gene Symbol: MAP2K2
MAP2K2
P36507 mitogen-activated protein kinase kinase 2 177 0.559 0.586 0.97 0.330 1.000 4 0 2007 2010
Entrez Id: 6655
Gene Symbol: SOS2
SOS2
Q07890 SOS Ras/Rho guanine nucleotide exchange factor 2 enzyme modulator 79 0.681 0.517 1.00 0.320 1.000 2 0 2016 2016
Entrez Id: 1969
Gene Symbol: EPHA2
EPHA2
P29317 EPH receptor A2 127 0.526 0.690 9.0E-06 0.310 1.000 2 0 2013 2014
Entrez Id: 23522
Gene Symbol: KAT6B
KAT6B
Q8WYB5 lysine acetyltransferase 6B nucleic acid binding; transcription factor; transferase 191 0.565 0.690 1.00 0.310 1.000 1 0 2011 2011
Entrez Id: 5922
Gene Symbol: RASA2
RASA2
Q15283 RAS p21 protein activator 2 enzyme modulator 93 0.667 0.483 1.5E-30 0.310 1.000 1 0 2014 2014
Entrez Id: 8216
Gene Symbol: LZTR1
LZTR1
Q8N653 leucine zipper like transcription regulator 1 96 0.630 0.517 2.2E-89 0.310 1.000 1 0 2016 2016
Entrez Id: 6237
Gene Symbol: RRAS
RRAS
P10301 RAS related enzyme modulator 95 0.636 0.552 4.5E-03 0.310 1.000 1 1 2016 2016
Entrez Id: 5921
Gene Symbol: RASA1
RASA1
P20936 RAS p21 protein activator 1 enzyme modulator 126 0.534 0.655 1.00 0.300 1 0 2017 2017
Entrez Id: 144568
Gene Symbol: A2ML1
A2ML1
A8K2U0 alpha-2-macroglobulin like 1 defense/immunity protein; enzyme modulator; signaling molecule 89 0.639 0.621 1.6E-34 0.300 0 0
Entrez Id: 4920
Gene Symbol: ROR2
ROR2
Q01974 receptor tyrosine kinase like orphan receptor 2 209 0.534 0.690 7.7E-04 0.200 4 0 2000 2011
Entrez Id: 144165
Gene Symbol: PRICKLE1
PRICKLE1
Q96MT3 prickle planar cell polarity protein 1 cytoskeletal protein; structural protein 53 0.645 0.621 1.00 0.200 1 0 2014 2014
Entrez Id: 55835
Gene Symbol: CENPJ
CENPJ
Q9HC77 centromere protein J receptor; transferase 107 0.596 0.586 5.2E-27 0.200 0 0
Entrez Id: 317
Gene Symbol: APAF1
APAF1
O14727 apoptotic peptidase activating factor 1 106 0.545 0.655 7.4E-06 0.200 0 0
Entrez Id: 80254
Gene Symbol: CEP63
CEP63
Q96MT8 centrosomal protein 63 cytoskeletal protein 53 0.648 0.414 4.0E-24 0.200 0 0
Entrez Id: 545
Gene Symbol: ATR
ATR
Q13535 ATR serine/threonine kinase kinase; nucleic acid binding; transferase 255 0.486 0.759 1.7E-08 0.200 0 0