Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.500 None 1.000 49 0 1994 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1 		P38398 BRCA1 DNA repair associated Enzyme 576 0.367 0.923 9.2E-29 0.500 None 0.978 45 1 1993 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 459 0.379 0.846 2.4E-25 0.500 None 0.947 19 1 1998 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.470 None 1.000 7 0 1986 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		P60484 phosphatase and tensin homolog Enzyme 983 0.305 0.923 0.26 0.460 None 1.000 6 0 2004 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.400 None 1.000 18 0 1989 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1 		P03372 estrogen receptor 1 Nuclear receptor 972 0.324 0.962 1.00 0.360 None 1.000 6 0 2003 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.360 None 1.000 6 0 2007 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.340 None 1.000 4 0 1998 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.340 None 1.000 4 2 2003 2014
Entrez Id: 51755
Gene Symbol: CDK12
CDK12 		Q9NYV4 cyclin dependent kinase 12 Kinase 41 0.638 0.462 1.00 0.330 None 1.000 3 0 2015 2016
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 1011 0.311 0.962 0.98 0.330 None 1.000 3 0 2007 2014
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1 		P24864 cyclin E1 Enzyme modulator 106 0.538 0.731 0.97 0.330 None 1.000 3 0 2014 2017
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		P43246 mutS homolog 2 Nucleic acid binding 404 0.406 0.808 0.90 0.320 None 1.000 2 0 2013 2014
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.320 None 0.500 2 0 2003 2004
Entrez Id: 54894
Gene Symbol: RNF43
RNF43 		Q68DV7 ring finger protein 43 56 0.584 0.577 0.73 0.310 None < 0.001 1 0 2013 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 396 0.401 0.808 0.15 0.310 None 1.000 1 0 2004 2004
Entrez Id: 208
Gene Symbol: AKT2
AKT2 		P31751 AKT serine/threonine kinase 2 Kinase 218 0.474 0.769 0.64 0.310 None 1.000 1 0 1996 1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1214 0.300 0.885 0.39 0.140 None 1.000 4 0 1997 2016
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C 		O43502 RAD51 paralog C 41 0.533 0.692 6.2E-14 0.120 None 1.000 2 0 2016 2018
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1 		Q13635 patched 1 339 0.398 0.885 1.00 0.110 None 1.000 1 0 2012 2012
Entrez Id: 94025
Gene Symbol: MUC16
MUC16 		Q8WXI7 mucin 16, cell surface associated 228 0.479 0.808 8.3E-112 0.100 None 0.923 13 0 1993 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		P15692 vascular endothelial growth factor A Signaling 1737 0.266 0.923 2.4E-05 0.100 None 1.000 11 0 1995 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		P08183 ATP binding cassette subfamily B member 1 Transporter 839 0.344 0.885 1.3E-05 0.080 None 1.000 8 0 1989 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1043 0.314 0.962 1.00 0.070 None 1.000 7 1 2003 2013