Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.540 strong 1.000 5 0 2007 2015
Entrez Id: 238
Gene Symbol: ALK
ALK
Q9UM73 ALK receptor tyrosine kinase 274 0.448 0.724 3.5E-06 0.500 1 0 2013 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
P00533 epidermal growth factor receptor 892 0.325 0.862 0.50 0.400 1.000 10 0 2002 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
O75874 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 235 0.463 0.690 3.3E-12 0.340 1.000 4 1 2010 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.320 1.000 2 0 2014 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
P42771 Q8N726 cyclin dependent kinase inhibitor 2A 891 0.321 0.828 0.38 0.310 1.000 3 0 1996 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
P15692 vascular endothelial growth factor A signaling molecule 1174 0.298 0.897 2.7E-05 0.310 1.000 2 0 2011 2017
Entrez Id: 1019
Gene Symbol: CDK4
CDK4
P11802 cyclin dependent kinase 4 kinase; transferase 266 0.449 0.724 7.8E-02 0.310 1.000 2 0 1996 2011
Entrez Id: 3558
Gene Symbol: IL2
IL2
P60568 interleukin 2 564 0.373 0.931 0.49 0.310 1.000 2 0 1984 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.310 1.000 1 0 2014 2014
Entrez Id: 595
Gene Symbol: CCND1
CCND1
P24385 cyclin D1 enzyme modulator 589 0.365 0.828 0.90 0.300 2 0 2011 2017
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
P01112 HRas proto-oncogene, GTPase enzyme modulator 545 0.404 0.828 8.7E-02 0.300 1 0 2017 2017
Entrez Id: 5727
Gene Symbol: PTCH1
PTCH1
Q13635 patched 1 386 0.435 0.759 1.00 0.300 1 0 1998 1998
Entrez Id: 5444
Gene Symbol: PON1
PON1
P27169 paraoxonase 1 324 0.443 0.828 9.0E-11 0.300 1 0 2005 2005
Entrez Id: 3689
Gene Symbol: ITGB2
ITGB2
P05107 integrin subunit beta 2 cell adhesion molecule; extracellular matrix protein; receptor 189 0.496 0.828 7.8E-15 0.300 1 0 2017 2017
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
P46937 Yes associated protein 1 149 0.514 0.655 1.00 0.300 1 0 2017 2017
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
P16455 O-6-methylguanine-DNA methyltransferase 293 0.438 0.759 1.1E-07 0.300 1 0 2010 2010
Entrez Id: 5970
Gene Symbol: RELA
RELA
Q04206 RELA proto-oncogene, NF-kB subunit nucleic acid binding; transcription factor 245 0.456 0.828 1.00 0.300 1 0 2011 2011
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
Q96EB6 sirtuin 1 hydrolase; nucleic acid binding 325 0.432 0.828 8.2E-02 0.300 1 0 2012 2012
Entrez Id: 5111
Gene Symbol: PCNA
PCNA
P12004 proliferating cell nuclear antigen nucleic acid binding 372 0.417 0.759 0.98 0.300 1 0 2011 2011
Entrez Id: 8826
Gene Symbol: IQGAP1
IQGAP1
P46940 IQ motif containing GTPase activating protein 1 enzyme modulator 65 0.600 0.586 1.00 0.300 1 0 2017 2017
Entrez Id: 28514
Gene Symbol: DLL1
DLL1
O00548 delta like canonical Notch ligand 1 108 0.538 0.690 1.00 0.300 1 0 2011 2011
Entrez Id: 10788
Gene Symbol: IQGAP2
IQGAP2
Q13576 IQ motif containing GTPase activating protein 2 enzyme modulator 30 0.713 0.207 2.1E-25 0.300 1 0 2017 2017
Entrez Id: 24147
Gene Symbol: FJX1
FJX1
Q86VR8 four jointed box 1 19 0.735 0.310 0.95 0.300 1 0 2017 2017
Entrez Id: 27436
Gene Symbol: EML4
EML4
Q9HC35 echinoderm microtubule associated protein like 4 55 0.614 0.448 2.5E-03 0.300 1 0 2013 2013