Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7428
Gene Symbol: VHL
VHL
P40337 von Hippel-Lindau tumor suppressor 293 0.464 0.586 5.5E-02 0.300 definitive 12 0 1991 2012
Entrez Id: 5979
Gene Symbol: RET
RET
P07949 ret proto-oncogene 452 0.418 0.724 1.00 0.300 definitive 12 0 1993 2017
Entrez Id: 6392
Gene Symbol: SDHD
SDHD
O14521 succinate dehydrogenase complex subunit D transfer/carrier protein 248 0.499 0.793 0.21 0.300 definitive 9 0 1997 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
P21912 succinate dehydrogenase complex iron sulfur subunit B oxidoreductase 207 0.513 0.690 3.4E-04 0.300 definitive 8 0 2001 2013
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
P31040 succinate dehydrogenase complex flavoprotein subunit A oxidoreductase 167 0.550 0.621 2.1E-10 0.300 definitive 8 0 2005 2013
Entrez Id: 6391
Gene Symbol: SDHC
SDHC
Q99643 succinate dehydrogenase complex subunit C 163 0.547 0.690 2.1E-04 0.300 definitive 8 0 2000 2013
Entrez Id: 55654
Gene Symbol: TMEM127
TMEM127
O75204 transmembrane protein 127 46 0.701 0.414 1.3E-02 0.300 definitive 8 0 2010 2013
Entrez Id: 4149
Gene Symbol: MAX
MAX
P61244 MYC associated factor X nucleic acid binding; transcription factor 84 0.604 0.586 0.85 0.300 definitive 7 0 1995 2015
Entrez Id: 54583
Gene Symbol: EGLN1
EGLN1
Q9GZT9 egl-9 family hypoxia inducible factor 1 65 0.594 0.552 0.98 0.300 moderate 6 0 2006 2015
Entrez Id: 54949
Gene Symbol: SDHAF2
SDHAF2
Q9NX18 succinate dehydrogenase complex assembly factor 2 72 0.627 0.483 3.8E-06 0.300 definitive 6 0 1982 2014
Entrez Id: 2271
Gene Symbol: FH
FH
P07954 fumarate hydratase lyase 162 0.533 0.690 9.2E-02 0.300 moderate 6 0 2005 2016
Entrez Id: 23095
Gene Symbol: KIF1B
KIF1B
O60333 kinesin family member 1B cytoskeletal protein 140 0.548 0.586 1.00 0.300 limited 5 0 2008 2014
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
Q99814 endothelial PAS domain protein 1 nucleic acid binding; transcription factor 153 0.509 0.586 0.50 0.300 disputed 3 0 2013 2016
Entrez Id: 8085
Gene Symbol: KMT2D
KMT2D
O14686 lysine methyltransferase 2D 203 0.520 0.724 1.00 0.300 limited 1 0 2016 2016
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
Q92560 BRCA1 associated protein 1 hydrolase; protease 186 0.488 0.586 0.99 0.300 limited 1 0 2013 2013
Entrez Id: 10461
Gene Symbol: MERTK
MERTK
Q12866 MER proto-oncogene, tyrosine kinase 119 0.557 0.690 2.7E-11 0.300 limited 1 0 2016 2016
Entrez Id: 4286
Gene Symbol: MITF
MITF
O75030 melanogenesis associated transcription factor 168 0.526 0.690 1.00 0.300 limited 1 0 2017 2017
Entrez Id: 4233
Gene Symbol: MET
MET
P08581 MET proto-oncogene, receptor tyrosine kinase 407 0.405 0.793 0.99 0.300 limited 1 0 2016 2016
Entrez Id: 4191
Gene Symbol: MDH2
MDH2
P40926 malate dehydrogenase 2 oxidoreductase 89 0.627 0.483 6.7E-03 0.300 limited 1 0 2015 2015
Entrez Id: 2668
Gene Symbol: GDNF
GDNF
P39905 glial cell derived neurotrophic factor signaling molecule 264 0.463 0.759 0.20 0.300 limited 1 0 1997 1997
Entrez Id: 112398
Gene Symbol: EGLN2
EGLN2
Q96KS0 egl-9 family hypoxia inducible factor 2 46 0.624 0.586 0.74 0.300 limited 1 0 2015 2015