Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.020 None 1.000 2 0 1994 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.020 None 1.000 2 0 2018 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 1308 0.295 0.885 0.37 0.010 None 1.000 1 0 2014 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1043 0.314 0.962 1.00 0.010 None 1.000 1 0 2005 2005
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1105 0.319 0.885 1.00 0.020 None 1.000 2 0 2018 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.020 None 1.000 2 0 2015 2015
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1087 0.320 0.885 1.4E-06 0.020 None 1.000 2 0 2018 2018
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB 		P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1077 0.322 0.885 1.00 0.020 None 1.000 2 0 2018 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274 		Q9NZQ7 CD274 molecule Receptor 990 0.324 0.923 1.9E-02 0.020 None 1.000 2 0 2017 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		P04626 erb-b2 receptor tyrosine kinase 2 Kinase 942 0.328 0.923 6.0E-03 0.020 None 1.000 2 0 2015 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		P42574 caspase 3 Enzyme 722 0.351 0.923 0.10 0.010 None 1.000 1 0 2013 2013
Entrez Id: 6696
Gene Symbol: SPP1
SPP1 		P10451 secreted phosphoprotein 1 715 0.353 0.885 2.1E-06 0.010 None 1.000 1 0 2004 2004
Entrez Id: 960
Gene Symbol: CD44
CD44 		P16070 CD44 molecule (Indian blood group) 664 0.363 0.962 2.4E-07 0.010 None 1.000 1 0 1999 1999
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		P09429 high mobility group box 1 Nucleic acid binding 671 0.368 0.923 0.82 0.010 None < 0.001 1 0 2019 2019
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 517 0.373 0.962 1.00 0.110 None 1.000 1 0 2015 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		P51587 BRCA2 DNA repair associated Nucleic acid binding 459 0.379 0.846 2.4E-25 0.020 None 1.000 2 0 2016 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.010 None 1.000 1 1 2019 2019
Entrez Id: 6657
Gene Symbol: SOX2
SOX2 		P48431 SRY-box transcription factor 2 Transcription factor 421 0.405 0.808 0.71 0.010 None 1.000 1 0 2006 2006
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5 		P06731 CEA cell adhesion molecule 5 423 0.420 0.846 4.2E-10 0.020 None 1.000 2 0 2017 2017
Entrez Id: 5328
Gene Symbol: PLAU
PLAU 		P00749 plasminogen activator, urokinase Enzyme 301 0.425 0.923 2.3E-06 0.010 None 1.000 1 0 2005 2005
Entrez Id: 4288
Gene Symbol: MKI67
MKI67 		P46013 marker of proliferation Ki-67 310 0.431 0.808 1.3E-28 0.010 None 1.000 1 0 1999 1999
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1 		P04798 cytochrome P450 family 1 subfamily A member 1 Enzyme 323 0.436 0.846 1.1E-17 0.010 None 1.000 1 2 2009 2009
Entrez Id: 57534
Gene Symbol: MIB1
MIB1 		Q86YT6 mindbomb E3 ubiquitin protein ligase 1 Enzyme 301 0.438 0.769 3.4E-88 0.010 None 1.000 1 0 1999 1999
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3 		P21860 erb-b2 receptor tyrosine kinase 3 Kinase 263 0.448 0.808 1.7E-15 0.010 None 1.000 1 0 2018 2018
Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4 		Q15303 erb-b2 receptor tyrosine kinase 4 Kinase 256 0.455 0.846 1.00 0.010 None 1.000 1 0 2018 2018