Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
Q96P20 NLR family pyrin domain containing 3 805 0.361 0.962 8.1E-04 0.800 None 1.000 31 2 2001 2017
Entrez Id: 58484
Gene Symbol: NLRC4
NLRC4
Q9NPP4 NLR family CARD domain containing 4 145 0.556 0.769 9.9E-12 0.720 None 1.000 2 2 2014 2019
Entrez Id: 4311
Gene Symbol: MME
MME
P08473 membrane metalloendopeptidase Enzyme 470 0.407 0.808 1.5E-18 0.300 None 1.000 1 0 2003 2003
Entrez Id: 5336
Gene Symbol: PLCG2
PLCG2
P16885 phospholipase C gamma 2 Enzyme 82 0.588 0.808 1.00 0.300 None 0 0
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
P01584 interleukin 1 beta 1801 0.276 0.962 0.13 0.090 None 1.000 9 0 2004 2018
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
P01583 interleukin 1 alpha 1002 0.333 0.962 1.6E-04 0.080 None 1.000 8 0 2004 2018
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
P18510 interleukin 1 receptor antagonist 701 0.373 0.923 3.1E-02 0.030 None 1.000 3 0 2004 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
P01375 tumor necrosis factor Signaling 2724 0.231 0.962 0.80 0.020 None 1.000 2 0 2007 2012
Entrez Id: 79054
Gene Symbol: TRPM8
TRPM8
Q7Z2W7 transient receptor potential cation channel subfamily M member 8 Ion channel 127 0.553 0.808 4.6E-29 0.020 None 1.000 2 0 2016 2019
Entrez Id: 834
Gene Symbol: CASP1
CASP1
P29466 caspase 1 Enzyme 444 0.413 0.885 3.5E-05 0.020 None 1.000 2 0 2005 2019
Entrez Id: 91662
Gene Symbol: NLRP12
NLRP12
P59046 NLR family pyrin domain containing 12 95 0.569 0.846 3.6E-28 0.020 None 1.000 2 1 2011 2016
Entrez Id: 4210
Gene Symbol: MEFV
MEFV
O15553 MEFV innate immuity regulator, pyrin 410 0.440 0.885 1.0E-14 0.020 None 1.000 2 0 2002 2003
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
P42345 mechanistic target of rapamycin kinase Kinase 960 0.343 0.885 1.00 0.020 None 1.000 2 0 2018 2018
Entrez Id: 51393
Gene Symbol: TRPV2
TRPV2
Q9Y5S1 transient receptor potential cation channel subfamily V member 2 Ion channel 90 0.581 0.615 7.9E-13 0.010 None 1.000 1 0 2018 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
P05231 interleukin 6 2367 0.248 0.962 0.32 0.010 None 1.000 1 0 2007 2007
Entrez Id: 6845
Gene Symbol: VAMP7
VAMP7
P51809 vesicle associated membrane protein 7 Transporter 69 0.612 0.577 1.4E-02 0.010 None 1.000 1 0 2016 2016
Entrez Id: 255061
Gene Symbol: TAC4
TAC4
Q86UU9 tachykinin precursor 4 24 0.711 0.462 3.6E-05 0.010 None 1.000 1 0 2019 2019
Entrez Id: 1233
Gene Symbol: CCR4
CCR4
P51679 C-C motif chemokine receptor 4 G-protein coupled receptor 168 0.510 0.731 6.9E-02 0.010 None 1.000 1 0 2018 2018
Entrez Id: 8569
Gene Symbol: MKNK1
MKNK1
Q9BUB5 MAPK interacting serine/threonine kinase 1 Kinase 73 0.606 0.808 8.0E-10 0.010 None 1.000 1 0 2017 2017
Entrez Id: 10855
Gene Symbol: HPSE
HPSE
Q9Y251 heparanase Enzyme 393 0.425 0.808 2.3E-14 0.010 None 1.000 1 0 2012 2012