Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 Kinase 297 0.460 0.808 1.2E-24 0.400 definitive 0.939 33 0 2000 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
P12830 cadherin 1 508 0.401 0.808 0.15 0.310 definitive 1.000 13 0 1991 2018
Entrez Id: 84464
Gene Symbol: SLX4
SLX4
Q8IY92 SLX4 structure-specific endonuclease subunit 123 0.565 0.731 1.6E-22 0.330 limited 1.000 10 0 2011 2017
Entrez Id: 4683
Gene Symbol: NBN
NBN
O60934 nibrin Nucleic acid binding 291 0.467 0.808 2.2E-16 0.340 limited 0.750 8 0 2000 2018
Entrez Id: 83990
Gene Symbol: BRIP1
BRIP1
Q9BX63 BRCA1 interacting protein C-terminal helicase 1 Enzyme 194 0.507 0.731 6.2E-17 0.080 None 0.875 8 0 2007 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 Nucleic acid binding 526 0.399 0.808 3.4E-05 0.320 disputed 1.000 8 0 2000 2017
Entrez Id: 10111
Gene Symbol: RAD50
RAD50
Q92878 RAD50 double strand break repair protein 110 0.556 0.808 3.4E-27 0.340 limited 0.714 7 0 2003 2017
Entrez Id: 79648
Gene Symbol: MCPH1
MCPH1
Q8NEM0 microcephalin 1 Nucleic acid binding 141 0.540 0.846 7.8E-30 0.310 limited 1.000 7 0 2005 2016
Entrez Id: 5965
Gene Symbol: RECQL
RECQL
P46063 RecQ like helicase Enzyme 58 0.615 0.615 1.5E-20 0.320 moderate 1.000 6 0 2005 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog Enzyme 1349 0.305 0.923 0.26 0.060 None 0.833 6 0 2002 2019
Entrez Id: 348654
Gene Symbol: GEN1
GEN1
Q17RS7 GEN1 Holliday junction 5' flap endonuclease 35 0.682 0.500 3.7E-15 0.300 disputed 1.000 6 0 2011 2016
Entrez Id: 60500
Gene Symbol: BRCA3
BRCA3
breast cancer 3 27 0.705 0.269 0.060 None 1.000 6 0 2007 2017
Entrez Id: 60561
Gene Symbol: RINT1
RINT1
Q6NUQ1 RAD50 interactor 1 19 0.743 0.231 5.3E-13 0.300 disputed 1.000 5 0 2001 2016
Entrez Id: 142
Gene Symbol: PARP1
PARP1
P09874 poly(ADP-ribose) polymerase 1 565 0.389 0.923 3.3E-04 0.050 None 1.000 5 0 2012 2015
Entrez Id: 1302
Gene Symbol: COL11A2
COL11A2
P13942 collagen type XI alpha 2 chain 399 0.435 0.846 0.70 0.040 None 1.000 4 0 2012 2015
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 244 0.484 0.808 4.5E-27 0.300 disputed 1.000 4 0 1995 2018
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
P24522 growth arrest and DNA damage inducible alpha 151 0.526 0.769 4.4E-02 0.030 None 0.667 3 0 2004 2018
Entrez Id: 7251
Gene Symbol: TSG101
TSG101
Q99816 tumor susceptibility 101 Enzyme 80 0.588 0.615 0.34 0.030 None 1.000 3 0 1998 2002
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
P05019 insulin like growth factor 1 1206 0.318 0.885 0.27 0.030 None 1.000 3 0 2005 2008
Entrez Id: 3294
Gene Symbol: HSD17B2
HSD17B2
P37059 hydroxysteroid 17-beta dehydrogenase 2 Enzyme 42 0.656 0.385 1.8E-10 0.030 None 1.000 3 0 1994 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11
Q15831 serine/threonine kinase 11 Kinase 372 0.435 0.808 0.99 0.030 None 1.000 3 0 2000 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
Q00987 MDM2 proto-oncogene Nucleic acid binding 702 0.362 0.846 1.00 0.030 None 0.667 3 0 2006 2011
Entrez Id: 55655
Gene Symbol: NLRP2
NLRP2
Q9NX02 NLR family pyrin domain containing 2 155 0.515 0.731 1.4E-38 0.030 None 0.667 3 0 2012 2014
Entrez Id: 5245
Gene Symbol: PHB
PHB
P35232 prohibitin 177 0.511 0.846 0.76 0.030 None 1.000 3 0 1992 2008
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1
Q9NS23 Ras association domain family member 1 Enzyme modulator 400 0.420 0.808 4.9E-06 0.030 None 0.667 3 0 2010 2014