Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
P37840 synuclein alpha Transporter 449 0.427 0.885 0.88 0.400 None 0.992 392 5 1998 2020
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
P10636 microtubule associated protein tau 469 0.446 0.923 6.0E-03 0.400 None 0.991 340 10 1998 2020
Entrez Id: 3064
Gene Symbol: HTT
HTT
P42858 huntingtin 188 0.548 0.654 1.00 0.100 None 1.000 231 0 1994 2020
Entrez Id: 23435
Gene Symbol: TARDBP
TARDBP
Q13148 TAR DNA binding protein 245 0.493 0.808 0.99 0.100 None 0.984 186 1 2006 2020
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
P00441 superoxide dismutase 1 Enzyme 689 0.379 0.962 0.18 0.100 None 0.986 146 4 1993 2020
Entrez Id: 5621
Gene Symbol: PRNP
PRNP
F7VJQ1 P04156 prion protein 426 0.445 0.923 6.3E-04 0.100 None 0.967 120 4 1991 2020
Entrez Id: 348
Gene Symbol: APOE
APOE
P02649 apolipoprotein E 1049 0.338 0.962 1.9E-03 0.100 None 0.967 92 0 1994 2019
Entrez Id: 2395
Gene Symbol: FXN
FXN
Q16595 frataxin Enzyme 220 0.510 0.654 0.34 0.100 None 0.988 84 0 1997 2020
Entrez Id: 2332
Gene Symbol: FMR1
FMR1
Q06787 FMRP translational regulator 1 Nucleic acid binding 346 0.473 0.769 0.65 0.100 None 0.986 72 0 2004 2019
Entrez Id: 2896
Gene Symbol: GRN
GRN
P28799 granulin precursor 412 0.435 0.846 7.0E-02 0.100 None 0.952 63 3 2006 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
P23560 brain derived neurotrophic factor Signaling 992 0.345 0.923 0.66 0.100 None 1.000 63 2 2001 2020
Entrez Id: 2521
Gene Symbol: FUS
FUS
P35637 FUS RNA binding protein Nucleic acid binding 301 0.470 0.846 1.00 0.100 None 1.000 61 0 2009 2020
Entrez Id: 4287
Gene Symbol: ATXN3
ATXN3
P54252 ataxin 3 Enzyme 207 0.521 0.808 0.11 0.100 None 1.000 59 1 1995 2020
Entrez Id: 3483
Gene Symbol: IGFALS
IGFALS
P35858 insulin like growth factor binding protein acid labile subunit Receptor 203 0.511 0.846 5.4E-11 0.100 None 0.983 58 1 1994 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
Q16236 nuclear factor, erythroid 2 like 2 Enzyme 823 0.357 0.885 3.6E-03 0.100 None 1.000 55 2 2009 2020
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
Q96LT7 C9orf72-SMCR8 complex subunit 258 0.496 0.769 1.1E-06 0.100 None 0.963 54 0 2012 2019
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
Q9NZC2 triggering receptor expressed on myeloid cells 2 239 0.519 0.769 3.3E-09 0.100 None 1.000 52 1 2007 2020
Entrez Id: 351
Gene Symbol: APP
APP
P05067 amyloid beta precursor protein Enzyme modulator 485 0.422 0.846 4.7E-02 0.400 None 0.935 46 0 1994 2019
Entrez Id: 6606
Gene Symbol: SMN1
SMN1
Q16637 survival of motor neuron 1, telomeric Epigenetic regulator 317 0.454 0.769 1.6E-02 0.100 None 1.000 42 1 2000 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
Q96EB6 sirtuin 1 Epigenetic regulator 675 0.378 0.885 8.7E-02 0.400 None 0.974 39 0 2007 2020
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
Q06546 GA binding protein transcription factor subunit alpha Transcription factor 632 0.379 0.885 1.00 0.100 None 1.000 38 0 2009 2020
Entrez Id: 1201
Gene Symbol: CLN3
CLN3
Q13286 CLN3 lysosomal/endosomal transmembrane protein, battenin Transporter 120 0.572 0.692 1.3E-07 0.100 None 1.000 34 0 1995 2019
Entrez Id: 1020
Gene Symbol: CDK5
CDK5
Q00535 cyclin dependent kinase 5 Kinase 204 0.495 0.846 0.14 0.100 None 1.000 31 0 2002 2019
Entrez Id: 6310
Gene Symbol: ATXN1
ATXN1
P54253 ataxin 1 218 0.534 0.769 0.97 0.400 None 1.000 30 0 1995 2020
Entrez Id: 6311
Gene Symbol: ATXN2
ATXN2
Q99700 ataxin 2 Nucleic acid binding 341 0.482 0.808 0.85 0.100 None 1.000 30 0 1995 2019