Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7428
Gene Symbol: VHL
VHL
P40337 von Hippel-Lindau tumor suppressor 293 0.464 0.586 5.5E-02 0.700 strong 0.944 37 0 1995 2018
Entrez Id: 2271
Gene Symbol: FH
FH
P07954 fumarate hydratase lyase 162 0.533 0.690 9.2E-02 0.600 strong 1.000 18 0 2005 2017
Entrez Id: 201163
Gene Symbol: FLCN
FLCN
Q8NFG4 folliculin 154 0.567 0.655 0.92 0.600 strong 1.000 13 0 2003 2017
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
Q92560 BRCA1 associated protein 1 hydrolase; protease 186 0.488 0.586 0.99 0.520 0.500 3 0 2014 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
P60484 phosphatase and tensin homolog hydrolase; phosphatase 915 0.334 0.828 0.82 0.400 strong 1.000 10 0 1998 2015
Entrez Id: 3558
Gene Symbol: IL2
IL2
P60568 interleukin 2 564 0.373 0.931 0.49 0.390 1.000 13 0 1992 2014
Entrez Id: 4233
Gene Symbol: MET
MET
P08581 MET proto-oncogene, receptor tyrosine kinase 407 0.405 0.793 0.99 0.390 strong 1.000 9 0 1997 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
P04637 tumor protein p53 transcription factor 1773 0.251 0.897 0.17 0.380 1.000 8 0 1993 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
P08183 ATP binding cassette subfamily B member 1 hydrolase; protease 606 0.371 0.828 1.3E-05 0.360 1.000 7 1 1988 2016
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
P50591 TNF superfamily member 10 signaling molecule 295 0.440 0.828 0.13 0.350 1.000 6 0 2001 2014
Entrez Id: 10397
Gene Symbol: NDRG1
NDRG1
Q92597 N-myc downstream regulated 1 hydrolase; protease 158 0.521 0.655 7.7E-03 0.330 1.000 4 0 2002 2005
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
P28482 mitogen-activated protein kinase 1 kinase; transferase 525 0.387 0.862 1.00 0.320 1.000 3 0 2009 2012
Entrez Id: 595
Gene Symbol: CCND1
CCND1
P24385 cyclin D1 enzyme modulator 589 0.365 0.828 0.90 0.320 1.000 3 0 2011 2012
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1
P04798 cytochrome P450 family 1 subfamily A member 1 oxidoreductase 262 0.458 0.828 1.2E-17 0.320 1.000 3 0 2004 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
P21912 succinate dehydrogenase complex iron sulfur subunit B oxidoreductase 207 0.513 0.690 3.4E-04 0.320 strong 1.000 2 0 2004 2013
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
P27361 mitogen-activated protein kinase 3 kinase; transferase 345 0.429 0.828 1.0E-01 0.310 1.000 2 0 2012 2017
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
P04049 Raf-1 proto-oncogene, serine/threonine kinase 328 0.462 0.793 0.89 0.310 1.000 2 0 2012 2015
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
P30711 glutathione S-transferase theta 1 356 0.419 0.862 1.3E-04 0.310 1.000 2 0 2008 2010
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
P46527 cyclin dependent kinase inhibitor 1B 334 0.424 0.724 0.66 0.310 1.000 2 0 2011 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
P15056 B-Raf proto-oncogene, serine/threonine kinase 871 0.352 0.793 1.00 0.310 1.000 2 0 2003 2012
Entrez Id: 7249
Gene Symbol: TSC2
TSC2
P49815 TSC complex subunit 2 enzyme modulator 290 0.463 0.690 1.00 0.300 3 0 2001 2011
Entrez Id: 3604
Gene Symbol: TNFRSF9
TNFRSF9
Q07011 TNF receptor superfamily member 9 85 0.565 0.621 0.27 0.300 1 0 2014 2014
Entrez Id: 1978
Gene Symbol: EIF4EBP1
EIF4EBP1
Q13541 eukaryotic translation initiation factor 4E binding protein 1 nucleic acid binding 119 0.529 0.793 0.21 0.300 1 0 2012 2012
Entrez Id: 6596
Gene Symbol: HLTF
HLTF
Q14527 helicase like transcription factor 34 0.663 0.276 9.3E-28 0.300 1 0 2006 2006
Entrez Id: 157570
Gene Symbol: ESCO2
ESCO2
Q56NI9 establishment of sister chromatid cohesion N-acetyltransferase 2 141 0.600 0.552 2.7E-07 0.300 1 0 2017 2017