Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
P40692 mutL homolog 1 nucleic acid binding 356 0.424 0.759 5.1E-05 1.000 definitive 0.950 548 490 1992 2018
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
P43246 mutS homolog 2 nucleic acid binding 320 0.437 0.690 0.91 0.900 0.963 506 443 1993 2018
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
P52701 mutS homolog 6 189 0.495 0.586 2.2E-05 0.700 0.940 215 231 1988 2018
Entrez Id: 5395
Gene Symbol: PMS2
PMS2
P54278 PMS1 homolog 2, mismatch repair system component nucleic acid binding 154 0.526 0.586 1.2E-27 0.700 0.976 137 78 1995 2018
Entrez Id: 4072
Gene Symbol: EPCAM
EPCAM
P16422 epithelial cell adhesion molecule 201 0.499 0.690 9.7E-08 0.700 1.000 21 7 2009 2018
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2
P37173 transforming growth factor beta receptor 2 kinase; receptor; transferase 361 0.437 0.793 0.15 0.590 1.000 10 0 1995 2015
Entrez Id: 27030
Gene Symbol: MLH3
MLH3
Q9UHC1 mutL homolog 3 nucleic acid binding 64 0.630 0.345 7.5E-08 0.560 0.833 7 0 2001 2016
Entrez Id: 22909
Gene Symbol: FAN1
FAN1
Q9Y2M0 FANCD2 and FANCI associated nuclease 1 54 0.659 0.414 1.9E-25 0.500 limited 4 0 2010 2016
Entrez Id: 324
Gene Symbol: APC
APC
P25054 APC, WNT signaling pathway regulator 462 0.397 0.828 1.00 0.400 0.941 17 1 1992 2015
Entrez Id: 5378
Gene Symbol: PMS1
PMS1
P54277 PMS1 homolog 1, mismatch repair system component nucleic acid binding 75 0.600 0.552 1.5E-16 0.400 1.000 15 0 1994 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
P01116 KRAS proto-oncogene, GTPase enzyme modulator 886 0.350 0.724 9.0E-04 0.400 0.800 10 0 1996 2014
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
P20585 mutS homolog 3 nucleic acid binding 158 0.507 0.621 8.1E-31 0.340 limited 0.750 9 0 1996 2017
Entrez Id: 9156
Gene Symbol: EXO1
EXO1
Q9UQ84 exonuclease 1 hydrolase; nucleic acid binding 36 0.672 0.448 8.7E-13 0.340 disputed 1.000 8 0 2000 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 835 0.341 0.897 1.00 0.330 1.000 3 0 2007 2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
O96017 checkpoint kinase 2 195 0.494 0.621 1.2E-23 0.320 limited 1.000 13 0 2003 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2
Q86YC2 partner and localizer of BRCA2 122 0.569 0.552 7.3E-20 0.310 limited 1.000 8 0 2013 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
P12830 cadherin 1 322 0.432 0.759 0.11 0.310 limited 1.000 7 0 1998 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
Q13315 ATM serine/threonine kinase kinase; nucleic acid binding; transferase 486 0.401 0.862 6.0E-46 0.310 moderate 1.000 7 0 2006 2017
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
P46527 cyclin dependent kinase inhibitor 1B 334 0.424 0.724 0.66 0.300 limited 8 0 1998 2015
Entrez Id: 580
Gene Symbol: BARD1
BARD1
Q99728 BRCA1 associated RING domain 1 54 0.624 0.379 2.2E-24 0.300 limited 4 0 2001 2016
Entrez Id: 2052
Gene Symbol: EPHX1
EPHX1
P07099 epoxide hydrolase 1 hydrolase; protease 150 0.510 0.759 3.7E-09 0.300 limited 3 0 1994 2015
Entrez Id: 6224
Gene Symbol: RPS20
RPS20
P60866 ribosomal protein S20 nucleic acid binding 10 0.773 0.172 2.4E-02 0.300 limited 2 0 2014 2017
Entrez Id: 64218
Gene Symbol: SEMA4A
SEMA4A
Q9H3S1 semaphorin 4A signaling molecule 74 0.616 0.517 1.8E-05 0.300 limited 2 0 2015 2017
Entrez Id: 79695
Gene Symbol: GALNT12
GALNT12
Q8IXK2 polypeptide N-acetylgalactosaminyltransferase 12 transferase 18 0.752 0.241 6.6E-06 0.300 limited 2 0 2004 2009
Entrez Id: 6597
Gene Symbol: SMARCA4
SMARCA4
P51532 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 nucleic acid binding 212 0.503 0.759 1.00 0.300 limited 2 0 2015 2016