Source: BEFREE ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 2245 0.236 0.962 0.53 0.030 None 1.000 3 1 2000 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		P01137 transforming growth factor beta 1 Signaling 1334 0.287 0.962 3.7E-02 0.010 None 1.000 1 0 2013 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1277 0.292 0.923 1.00 0.020 None 1.000 2 0 2017 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A 		P42771 Q8N726 cyclin dependent kinase inhibitor 2A 1214 0.300 0.885 0.39 0.010 None < 0.001 1 0 2006 2006
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 1156 0.303 0.885 1.00 0.040 None 0.750 4 0 2001 2011
Entrez Id: 207
Gene Symbol: AKT1
AKT1 		P31749 AKT serine/threonine kinase 1 Kinase 1011 0.311 0.962 0.98 0.010 None 1.000 1 0 2017 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 888 0.319 0.846 1.00 0.030 None 1.000 3 0 2012 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 805 0.320 0.923 7.9E-04 0.060 None 1.000 6 2 2007 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		P40763 signal transducer and activator of transcription 3 Nucleic acid binding 999 0.320 0.923 1.00 0.010 None < 0.001 1 0 2017 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274 		Q9NZQ7 CD274 molecule Receptor 990 0.324 0.923 1.9E-02 0.010 None 1.000 1 0 2019 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		Q16552 interleukin 17A 1034 0.324 0.923 4.3E-02 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 816 0.337 0.885 3.2E-10 0.010 None 1.000 1 1 2015 2015
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		P05121 serpin family E member 1 Enzyme modulator 706 0.359 0.885 4.4E-02 0.010 None 1.000 1 0 2017 2017
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 681 0.362 0.923 1.8E-02 0.010 None 1.000 1 1 2015 2015
Entrez Id: 960
Gene Symbol: CD44
CD44 		P16070 CD44 molecule (Indian blood group) 664 0.363 0.962 2.4E-07 0.030 None 1.000 3 0 2001 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		microRNA 21 705 0.363 0.846 0.010 None 1.000 1 0 2017 2017
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3 		Q9BZS1 forkhead box P3 622 0.368 0.846 0.99 0.010 None 1.000 1 0 2011 2011
Entrez Id: 7431
Gene Symbol: VIM
VIM 		P08670 vimentin 592 0.372 0.846 0.71 0.020 None 1.000 2 0 2018 2020
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 517 0.373 0.962 1.00 0.010 None 1.000 1 0 2003 2003
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		P27361 mitogen-activated protein kinase 3 Kinase 577 0.379 0.885 3.7E-02 0.010 None 1.000 1 0 2017 2017
Entrez Id: 4233
Gene Symbol: MET
MET 		P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 501 0.380 0.846 0.97 0.020 None 1.000 2 0 2014 2016
Entrez Id: 4582
Gene Symbol: MUC1
MUC1 		P15941 mucin 1, cell surface associated 552 0.384 0.885 1.9E-02 0.010 None 1.000 1 0 2013 2013
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1 		Q15672 twist family bHLH transcription factor 1 Transcription factor 436 0.397 0.846 0.34 0.020 None 1.000 2 0 2015 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 446 0.399 0.808 3.4E-05 0.010 None 1.000 1 0 2019 2019
Entrez Id: 4311
Gene Symbol: MME
MME 		P08473 membrane metalloendopeptidase Enzyme 405 0.407 0.808 1.5E-18 0.010 None 1.000 1 0 2013 2013