Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE Preliminary data indicate that recombinant C-type natriuretic peptide (CNP) is safe in children and increases growth velocity upon 42 months of treatment in achondroplasia. 31789832 2020
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE SIGNIFICANCE STATEMENT: The hormone C-type natriuretic peptide (CNP) is in clinical development for the treatment of comorbidities associated with achondroplasia, the most common form of human dwarfism. 31235532 2019
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia. 31269546 2019
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE There are successes with the use of growth hormone in individuals with SHOX deficiencies, asfotase alfa in hypophosphatasia, and some promising data for c-type natriuretic peptide for those with achondroplasia. 28808977 2017
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE These results clearly demonstrate the therapeutic potential of CNP for treatment of midfacial hypoplasia and foramen magnum stenosis in achondroplasia. 28644737 2017
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE C-Type Natriuretic Peptide Analog as Therapy for Achondroplasia. 26684019 2016
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 GeneticVariation disease BEFREE Subcutaneous administration of one of these CNP variants (BMN 111) resulted in correction of the dwarfism phenotype in a mouse model of ACH and overgrowth of the axial and appendicular skeletons in wild-type mice without observable changes in trabecular and cortical bone architecture. 25650377 2015
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE A phase 2 multicenter and multinational trial is being developed to evaluate a CNP analog treatment for achondroplasia. 25196103 2014
Entrez Id: 4880
Gene Symbol: NPPC
NPPC
0.090 Biomarker disease BEFREE We have shown that targeted overexpression of CNP in cartilage or systemic administration of CNP reverses the impaired skeletal growth of mice model of achondroplasia, the most common form of human skeletal dysplasias. 20567091 2010