Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.130 Biomarker disease HPO
Entrez Id: 26580
Gene Symbol: BSCL2
BSCL2 		0.100 Biomarker disease HPO
Entrez Id: 10555
Gene Symbol: AGPAT2
AGPAT2 		0.100 Biomarker disease HPO
Entrez Id: 286053
Gene Symbol: NSMCE2
NSMCE2 		0.100 Biomarker disease HPO
Entrez Id: 4000
Gene Symbol: LMNA
LMNA 		0.100 Biomarker disease HPO
Entrez Id: 3155
Gene Symbol: HMGCL
HMGCL 		0.100 Biomarker disease HPO
Entrez Id: 374569
Gene Symbol: ASPG
ASPG 		0.030 Biomarker disease BEFREE Acute pancreatitis is one of the common causes of asparaginase intolerance. 27114598 2016
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN 		0.030 Biomarker disease BEFREE IL-1RN appears to determine severity of acute pancreatitis and susceptibility to idiopathic acute pancreatitis. 10766448 2000
Entrez Id: 1080
Gene Symbol: CFTR
CFTR 		0.100 GeneticVariation disease BEFREE CFTR mutations and SPINK-1 polymorphisms are frequent among HIV-positive patients suffering from acute pancreatitis. 15238770 2004
Entrez Id: 929
Gene Symbol: CD14
CD14 		0.050 GeneticVariation disease BEFREE CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis. 16273622 2005
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.100 GeneticVariation disease BEFREE Toll-like receptor 4 Asp299Gly polymorphism is associated with the infection of pancreatic necrosis in AP. 17414051 2007
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.070 Biomarker disease BEFREE Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. 17940904 2008
Entrez Id: 2153
Gene Symbol: F5
F5 		0.010 Biomarker disease BEFREE Factor V Leiden was identified in 5 (3.3%) of 152 cases of severe AP and in 8 (3.3%) of 245 cases of mild AP. 19248219 2009
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.010 Biomarker disease BEFREE Activated protein C improves the severity of severe acute pancreatitis via up-regulating the expressions of endothelial cell protein C receptor and thrombomodulin. 19680809 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 Biomarker disease BEFREE Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis. 20937337 2011
Entrez Id: 51083
Gene Symbol: GAL
GAL 		0.010 Biomarker disease BEFREE Galanin participates in the pathogenesis of acute pancreatitis (AP). 21303427 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.100 AlteredExpression disease BEFREE TNFA promoter variants do not alter susceptibility to AP, but rather the TNF-α expression-enhancing -1031C and -863A alleles significantly increased the risk of AP progression to MODS. 22487520 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.100 Biomarker disease BEFREE Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. 24572992 2014
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1 		0.020 Biomarker disease BEFREE Angiopoietin-1 gene-modified human mesenchymal stem cells promote angiogenesis and reduce acute pancreatitis in rats. 25120736 2014
Entrez Id: 1364
Gene Symbol: CLDN4
CLDN4 		0.010 AlteredExpression disease BEFREE Claudin-4 expression was reduced in duodenal biopsies in AP patients (P<0.001 for crypt intercellular junction and P=0.007 for crypt cytoplasm). 27466164 2019
Entrez Id: 5697
Gene Symbol: PYY
PYY 		0.020 Biomarker disease BEFREE Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after AP and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFα. 27918953 2017
Entrez Id: 100188881
Gene Symbol: MFT2
MFT2 		0.010 Biomarker disease BEFREE TEM revealed that the spleen T-lymphocytes were normal in AP rats, but pyroptotic and necrotic spleen B-cells were observed in the severe AP rats. 27920277 2017
Entrez Id: 64102
Gene Symbol: TNMD
TNMD 		0.010 Biomarker disease BEFREE TEM revealed that the spleen T-lymphocytes were normal in AP rats, but pyroptotic and necrotic spleen B-cells were observed in the severe AP rats. 27920277 2017
Entrez Id: 1540
Gene Symbol: CYLD
CYLD 		0.010 Biomarker disease BEFREE TEM revealed that the spleen T-lymphocytes were normal in AP rats, but pyroptotic and necrotic spleen B-cells were observed in the severe AP rats. 27920277 2017
Entrez Id: 64170
Gene Symbol: CARD9
CARD9 		0.020 Biomarker disease BEFREE CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9-dependent NF-κB and P38MAPKs pathway. 27957800 2017