Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Perioperative chemotherapy with or without epidermal growth factor receptor blockade in unselected patients with locally advanced oesophagogastric adenocarcinoma: Randomized phase II study with advanced biomarker program of the German Cancer Society (AIO/CAO STO-0801). 29501977 2018
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE The patients were first grouped according to the primary tumor histology (adenocarcinoma, small-cell lung cancer, squamous cell carcinoma), and those with adenocarcinoma were further divided into <i>epidermal growth factor receptor</i> (<i>EFGR</i>) mutation-positive and wild type groups. 29301782 2018
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas. 29960043 2018
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma. 28144970 2017
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE In addition, the <i>epidermal growth factor receptor</i> mutation rate was higher in the adenocarcinoma histologic type (p<0.001). 28832323 2017
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE Expert consensus guidelines have defined minimum requirements for routine testing and identification of classical epidermal growth factor (EGFR) mutations (ie, exon 19 deletions and exon 21 L858R substitution) and anaplastic lymphoma kinase (ALK) rearrangements in advanced non-small-cell lung cancers of adenocarcinoma histology, with the intent of permitting use of these predictive biomarkers to select patients who will derive maximal benefit from approved oral tyrosine kinase inhibitors (TKIs) directed against EGFR and ALK, respectively. 27381270 2016
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 AlteredExpression group BEFREE The expression of epidermal growth factor-like domain-containing protein 7 (EGFL7) was detected in the normal gastric mucosa epithelial GES-1 cell line and three different differentiation GC cell lines, including MKN28 (well-differentiated adenocarcinoma), SGC7901 (moderately differentiated adenocarcinoma) and BGC823 (poorly differentiated adenocarcinoma). 27259812 2016
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE This study aimed to evaluate the role of the EGF +61A/G polymorphism in risk of NSCLC adenocarcinoma (ADC) occurrence and survival in an Indian population. 26625757 2015
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group CTD_human Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells. 23064031 2013
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE Polymerase chain reaction restriction fragment length polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls.All subjects were Caucasian. 21274378 2011
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Immunohistochemical detection of mutated epidermal growth factor receptors in pulmonary adenocarcinoma. 21187519 2010
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. 18704599 2008
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group LHGDN A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. 18483390 2008
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Our data suggest that methylation of transmembrane protein containing epidermal growth factor and folistatin domains/hyperplastic polyposis 1 is present in the majority of gastric adenocarcinomas and in the surrounding tumoural-free area, indicating that this epigenetic change may point to a field effect in the gastric mucosa. 18799374 2008
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 AlteredExpression group BEFREE There was a significant difference between the median EGF gene expression among the three genotypes in normal colon (p < 0.001) but not in adenocarcinomas. 17851837 2007
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE We analyzed exons 19 and 21 coding for the receptor tyrosine kinase of the epidermal growth factor gene in 105 samples of esophageal (Barrett's) adenocarcinoma by denaturing high-pressure liquid chromatography. 17227303 2007
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE Clinical predictors including Asian, female, adenocarcinoma and never-smoker and epidermal growth factor mutation are associated with gefitinib responsiveness in non-small-cell lung cancer. 16956694 2006
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Many adenocarcinoma lesions were positive for EGF and EGFR. 16774944 2006
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 AlteredExpression group BEFREE In terms of the clinical situation, MVD in the normal mucosa surrounding colorectal adenocarcinomas correlated with patient serum gastrin levels and HB-EGF expression. 16585174 2006
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Mucin biosynthesis: epidermal growth factor downregulates core 2 enzymes in a human airway adenocarcinoma cell line. 12600830 2003
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE We examined the effect of EGF on motility, migration, and morphology of a human adenocarcinoma cell line CAC-1. 12749846 2003
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 AlteredExpression group BEFREE We performed immunohistochemical analysis on 61 adenocarcinoma tissues for the expression of EGF, EGFR, and cyclin D1 and demonstrated an overexpression in the tumor cells in 51%, 54%, and 62.3%, respectively, whereas normal human pancreas stained negative for all of the three factors. 11590324 2001
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 Biomarker group BEFREE Dose-dependent reduction in EGF-stimulated A549 motility was observed with the PD98059 MEK1 inhibitor and the batimastat (BB-94) inhibitor of MMP activity, but not with the SB203580 inhibitor of p38 kinase. 11585739 2001
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 AlteredExpression group BEFREE We conclude that inhibition of tyrosine kinase activity other than the EGF receptor decreases the expression of surfactant protein A at a pretranslational level in human pulmonary adenocarcinoma cells. 9060993 1997
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.400 GeneticVariation group BEFREE Southern blot analysis of DNAs isolated from 25 ovarian adenocarcinomas revealed no amplification of the IGF-I-R or the EGF-R gene. 1325950 1992