Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE In contrast to the 44% rate of APC mts in AC group, only 3% of SRCC patients had APC mts (OR = 0.04). 31406299 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE APC mutations were identified in duodenal adenomas more frequently than in duodenal ACs, which differed from the observations of typical adenoma-carcinoma sequences seen in colorectal cancer, suggesting the limited involvement of this mechanism in duodenal cancer development. 29525853 2018
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE Compared with colorectal adenocarcinomas, mixed adenoneuroendocrine carcinomas were more frequently BRAF (37%; P=0.006), and less frequently KRAS (21%; P=0.043) and APC (16%; P=0.001) mutated. 28059096 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Molecular analyses revealed the gene mutations of GNAS in 6 (38%) of 16 DNGPs (4 [57%] adenomas, 1 [16%] NUMP, and 1 [33%] invasive adenocarcinoma) and APC in 4 of 15 (27%) DNGPs: no adenomas, 2 (33%) NUMPs, and 2 (67%) invasive adenocarcinomas. 27984236 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE This autosomal-dominant syndrome is caused by germline mutations in the gene coding for the protein APC and leads to hyperactivation of the WNT/β-catenin signaling pathway, uncontrolled intestinal cell proliferation and formation of adenocarcinomas. 29156563 2017
Entrez Id: 324
Gene Symbol: APC
APC
0.400 AlteredExpression group BEFREE Our results showed two hypomethylated genes (CDKN2A and MGMT) and three hypermethylated genes (CDH13, RUNX3 and APC) in ACs compared with SCCs. 26862903 2016
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Formalin Fixed Paraffin Embedded tissue were studied for miRNA expression, KRAS, BRAF, PIK3CA mutations, and immuno-histochemistry for APC and p53 proteins for normal colon (n=11), hyperplastic polyps (n=11), high grade adenomas (n=10), low grade adenomas (n=34) and adenocarcinoma (n=13). 25496852 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Most sporadic colonic adenocarcinomas are microsatellite stable (MSS) and arise from conventional adenomas by dysregulation of the APC/β-catenin/Wnt signaling pathway. 25602793 2015
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE APC, KRAS, and BRAF mutations were identified in five, 11, and one lesion, respectively, and most of these mutations were shared between the villous adenoma and the adenocarcinoma components in the respective lesions, except in one lesion with APC mutations and in two lesions with KRAS mutations. 24470207 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. 25344691 2014
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification group BEFREE In contrast, 39% of the specimens showed APC methylation, which was more common in ADC (58%) than in SCC (13%). 22542170 2012
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression. 22262720 2012
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE Loss of DCC-induced apoptosis is also associated with an increase in the number and aggressiveness of intestinal tumours in a predisposing APC mutant context, resulting in the development of highly invasive adenocarcinomas. 22158121 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification group BEFREE EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. 21538028 2011
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification group BEFREE EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. 20978327 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE Forty-eight small bowel adenocarcinomas (33 non-celiac disease related and 15 celiac disease related) were characterized for chromosomal aberrations by high-resolution array comparative hybridization, microsatellite instability, and APC promoter methylation and mutation status. 20179237 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Could APC gene screening be useful in children with hepatoblastoma? Early onset of adenocarcinoma in a child with familial adenomatous polyposis and hepatoblastoma. 20210251 2010
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Preoperative measurement of methylated DAPK and APC promoter DNA in peripheral blood may contribute to better estimate postoperative survival chances of patients with esophageal carcinoma, especially adenocarcinoma. 19259700 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.400 GeneticVariation group BEFREE Alterations of APC, KRAS and TP53 were observed in a higher percentage of adenocarcinomas compared to adenomas (P<0.05) indicating that the alterations accumulated with malignancy. 19576232 2009
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE We analyzed the phenotypes, DNA ploidy patterns, and microsatellite regions linked to adenomatous polyposis coli (APC) gene on chromosome 5q of low-grade gastric adenomas/dysplasias, Vienna Category 3, to investigate whether these lesions have the potential to become adenocarcinomas. 17964080 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group LHGDN We analyzed the phenotypes, DNA ploidy patterns, and microsatellite regions linked to adenomatous polyposis coli (APC) gene on chromosome 5q of low-grade gastric adenomas/dysplasias, Vienna Category 3, to investigate whether these lesions have the potential to become adenocarcinomas. 17964080 2008
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE The APC gene was therefore sequenced in 90 colonic adenocarcinomas previously evaluated for CIMP, microsatellite instability, BRAF, Ki-ras, and p53. 17293392 2007
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification group LHGDN In comparison with adenocarcinomas of the stomach, SB-AC revealed a significantly higher rate of hypermethylation of HPP1 (86% versus 54%, p = 0.0003), p16(INK4A) (32% versus 10%, p = 0.0006), and a significantly lower rate of hypermethylation of APC (48% versus 84%, p = 0.0001). 16619216 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.400 PosttranslationalModification group BEFREE A distinct profile was apparent for the 2 groups of lung tumors and the frequencies of promoter hypermethylation at sFRP1 and WIF-1, 2 genes involved in Wnt signaling, and at CDH1 were significantly higher in colorectal metastases than in lung primaries, whereas methylation of the APC promoter was significantly more common in lung primary adenocarcinomas. 16991125 2006
Entrez Id: 324
Gene Symbol: APC
APC
0.400 Biomarker group BEFREE Combining 4 genes (CALCA, DAPK, ESR1 and APC) yielded a sensitivity of 89% (with all adenocarcinomas identified), equal to cytomorphology (89%) and high-risk human papilloma virus (Hr-HPV; 90%). 16736496 2006