Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group BEFREE Inhibition of Lipopolysaccharide-Induced Interleukin 8 in Human Adenocarcinoma Cell Line HT-29 by Spore Probiotics: B. coagulans and B. subtilis (natto). 27785697 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation group BEFREE Interleukin 8 (IL-8) mediates the angiogenesis of tumors arising from Ras mutations, which are present in about 90% of pancreatic adenocarcinomas. 27749658 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE Our findings suggest that IL-8 expression is associated with certain clinicopathological features including age and is a potent prognostic marker in lung adenocarcinoma, especially in oncogenic KRAS-driven adenocarcinoma. 24577055 2014
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group BEFREE Brachyury mRNA expression was significantly inversely correlated to E-cadherin expression (P = 0.0252) and positively correlated to IL-8 protein (P = 0.0241) and to Slug protein (P = 0.0243) in adenocarcinoma tissues. 23456319 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group BEFREE Higher IL-8 production was found for both SCC and AdC compared to controls. 23441128 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation group BEFREE Clinical analysis indicated a borderline positive association of IL-8 -251T allele among adenocarcinoma patients (P=0.003). 23831257 2013
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group BEFREE These results indicate that activating mutations of KRAS or EGFR upregulate IL-8 expression in NSCLC; IL-8 is highly expressed in NSCLCs from males, smokers, elderly patients, NSCLCs with pleural involvement, and KRAS-mutated adenocarcinomas; and IL-8 plays a role in cell growth and migration in oncogenic KRAS-driven NSCLC. 21544811 2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group BEFREE In this study, we provide evidence that interleukin 8 (IL8)-CXCR2-P53 (TP53) signaling pathway keeps the NE cells of benign prostate and adenocarcinoma in a quiescent state normally. 22389383 2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE DNA promoter methylation status and protein expression of interleukin-8 in human colorectal adenocarcinomas. 22108905 2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 GeneticVariation group BEFREE Interleukin-8-251A/T polymorphism and Helicobacter pylori infection influence risk for the development of gastric cardiac adenocarcinoma in a high-incidence area of China. 20300863 2010
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE CXCL8 expression correlated with nuclear beta-catenin localization in epithelial cells of adenomas, but was associated with endothelial cells and neutrophils in the adenocarcinomas. 19173296 2009
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 Biomarker group CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536 2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE Patients with the highest IL-8 expression were those with Barrett's dysplasia and adenocarcinoma (P<.001). 17576892 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group LHGDN Differential regulation of RANTES and IL-8 expression in lung adenocarcinoma cells. 17207890 2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE Pretreatment of HT29-D4 epithelial adenocarcinoma colic cells with des-IGF-1 upregulated TNF alpha-mediated activation of IL-8 expression at different levels (protein, mRNA, and hnRNA). 12767906 2003
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.400 AlteredExpression group BEFREE In this study we evaluated, for the first time, IL-8 messenger RNA (mRNA) expression in non-small-cell lung cancer (NSCLC), using real-time quantitative reverse-transcription-polymerase chain reaction, and correlated IL-8 mRNA expression in tumor and nontumor lung samples from 58 patients with NSCLC (29 with squamous cell carcinoma and 29 with adenocarcinoma, of whom 20 had Stage I, 10 had Stage II, and 28 had Stage III disease) with these patients' clinicopathologic characteristics, angiogenesis, and outcome. 11069840 2000