Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation group BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group BEFREE They showed a significant reduction in aberrant crypt foci formation and adenocarcinoma count along with a significant (p<0.05) reduction in TNF-α levels as compared to DMH control at 100 mg/kg dose. 28694750 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Therapeutic group CTD_human MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. 19028472 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group CTD_human MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. 19028472 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group LHGDN Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis. 18316608 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group BEFREE We have previously demonstrated that solamargine (SM), the major steroidal glycoalkaloid extracted from Chinese herb Solanum plants, reveals down-regulation of HER2 and up-regulation of Fas and tumor necrosis factor receptor (TNFR) expressions, triggers the mitochondria-mediated cell apoptosis pathway, and sensitizes human nonsmall cell lung cancer (NSCLC) H441 and A549 adenocarcinoma cells to chemotherapy. 18078328 2008
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group BEFREE In vivo stimulation experiments in the adenocarcinoma cell line LS174T showed inducible mucin expression by the cytokines tumor necrosis factor-alpha and transforming growth factor-beta, which could be blocked by NFkappaB signaling inhibitors. 17058067 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. 16467113 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Adenovirus-mediated gene transfer of caspase-8 sensitizes human adenocarcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand. 15645141 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation group BEFREE Polymorphisms in tumor necrosis factor genes and susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a population of high incidence region of North China. 16313841 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group LHGDN Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. 15870936 2005
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group LHGDN NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis. 12032830 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/Apo2L has been recently identified as important in promoting programmed cell death in breast and colon adenocarcinomas. 10960444 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 AlteredExpression group BEFREE We demonstrate for the first time TNF-alpha dose-dependent induction of TRAF1 protein and messenger RNA (mRNA) in human H441 and A549 pulmonary adenocarcinoma cell lines, as well as in lung cells of C57BL/6J mice after intratracheal administration of TNF-alpha. 10657935 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 GeneticVariation group BEFREE We investigated the levels of manganese superoxide dismutase (Mn SOD), its inducibility, and its protective role against tumor necrosis factor-alpha and cytotoxic drugs (cisplatin, epirubicin, methotrexate, and vindesin) in human pleural mesothelioma (M14K) and pulmonary adenocarcinoma (A549) cells. 10749746 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE In situ hybridization performed in four cases (three LC positive and one LC negative) of squamous cell carcinoma and in five cases (four LC positive and one LC negative) of adenocarcinoma showed that some mononuclear cells in the interstitium displayed hybridization with granulocyte macrophage-colony stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF alpha), and interleukin 1-beta (IL1 beta) cDNA probes. 7635448 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor. 7592709 1995
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Although neoplastic cells in both low and high grade endometrial tumors contained TNF-alpha mRNA, two major differences were observed: HS for TNF-alpha mRNA were significantly less in low grade than in high grade neoplasms, and TNF-alpha message was restricted to the nucleus in low grade adenocarcinoma cells but was abundant in the cytoplasm of high grade tumor cells. 8001927 1994
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Down-modulation of epidermal growth factor receptor accompanies TNF-induced differentiation of the DiFi human adenocarcinoma cell line toward a goblet-like phenotype. 8227158 1993
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group CTD_human Effects on tumour microcirculation in mice of misonidazole and tumour necrosis factor plus hyperthermia. 1733439 1992
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Therapeutic group CTD_human Effects on tumour microcirculation in mice of misonidazole and tumour necrosis factor plus hyperthermia. 1733439 1992
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker group BEFREE Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells. 1906154 1991