Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Increased expression of pro-angiogenic factors and vascularization in thyroid hyperfunctioning adenomas with and without TSH receptor activating mutations. 22815044 2013
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Whether hereditary or somatic after birth, activating mutations of the TSH receptor have the same qualitative consequences on the thyroid cell phenotype, but somatic mutations in AAs have a much stronger effect than FNAH mutations. 19383781 2009
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE In cases with somatic mutations of the TSHR, simple resection of the adenoma is sufficient, whereas total thyroidectomy should be considered in patients with germ cell mutations. 19492584 2009
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE To perform (i) an immunohistochemical investigation of cell proliferation, apoptosis, angiogenesis, and malignancy markers in 15 functioning and 15 nonfunctioning thyroid adenomas, and in normal adjacent tissue, and (ii) a genetic analysis of thyroid-stimulating hormone receptor (TSH-r), Gsalpha, and RAS mutations in the same group of adenomas, in order to describe their expression within tissues and to correlate them with the hormonal functioning. 17381350 2007
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 Biomarker group BEFREE Somatic activating mutations of the thyrotropin (thyroid-stimulating hormone (TSH)) receptor (TSHR) and G(alphas) protein have been detected in solitary toxic adenomas and toxic multinodular goiters, but their role in the pathogenesis of autonomous nodules is debated. 14514342 2003
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions. 12804102 2003
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 Biomarker group BEFREE The absence of a significant difference between the adenoma and the surrounding normal tissue was maintained after dividing the patients into two groups, according to TSH receptor status. 12039695 2002
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE For instance, mutations of the gsp and thyroid-stimulating hormone receptor genes are associated with benign hyperfunctioning thyroid nodules and adenomas while alterations of other specific genes, such as oncogenic tyrosine kinase alterations (RET/PTC, TRK) in papillary carcinoma and the newly discovered PAX8/peroxisome proliferator-activated receptor gamma rearrangement, are distinctive features of cancer. 12665646 2002
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Whilst activating mutations in the TSH receptor or in the Gs alpha-subunit, which increase cAMP levels, have been shown to be responsible for 80% of the autonomous adenomas, no such mutations have been observed in the other types of thyroid tumors, suggesting that other mechanisms exist. 11375794 2001
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Sequencing of all exons of the TSHR gene in one family with hyperthyroidism revealed a mutation in exon 10 (T6321), which was first identified in toxic adenomas and found to constitutively activate the TSHR. 11127522 2000
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Constitutive activation of the cAMP signal transduction system has been documented in thyroid autonomously hyperfunctioning adenomas in which activating mutations in either the TSH receptor gene or the Gsalpha protein gene (gsp oncogene) have been described. 10650954 2000
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Six of seven adenomas harbored heterozygous mutations known to confer constitutive activity to the TSH receptor. 10595453 1999
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE The expression of 4 thyroid tissue-specific genes [Na+/I- symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (Tg), TSH receptor (TSH-R)] as well as of the glucose transporter type 1 (Glut1) gene was analyzed in 90 human thyroid tissues Messenger ribonucleic acids were extracted from 43 thyroid carcinomas (38 papillary and 5 follicular), 24 cold adenomas, 5 Graves' thyroid tissues, 8 toxic adenomas, and 5 hyperplastic thyroid tissues; 5 normal thyroid tissues were used as reference. 10487692 1999
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE However, TSH receptor and Gs-alpha gene mutations alone are not sufficient to cause toxic adenomas and nodules. 9867188 1998
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Activating mutations of the TSH receptor and alpha-subunit of Gs (G alpha s) that increase adenylyl cyclase activity have been identified in a subset of hyperfunctioning benign thyroid follicular adenomas and, less commonly, in hypofunctioning adenomas and carcinomas. 9467574 1998
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Thyroid hyperfunctioning adenomas with and without Gsp/TSH receptor mutations show similar clinical features. 9710366 1998
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Activating thyrotropin (TSH) receptor mutations have been found in toxic adenomas and in hot nodules contained in toxic multinodular goiter. 9709907 1998
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 AlteredExpression group BEFREE Mutated forms of the TSH receptor (TSHR) and the adenylyl cyclase-activating Gs alpha protein, which confer a constitutive activity on these proteins, have been observed in human adenomas. 9519872 1998
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE These data provide a molecular link between the occurrence of TSH receptor mutations and thyroid autonomously functioning adenomas. 9266964 1997
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE A more intense signal was observed in toxic adenomas and in samples obtained from a patient with severe hyperthyroidism due to an activating mutation in the TSH receptor. 9225730 1997
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas. 8636365 1996
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE However, the widely varying thyroid phenotypes in patients with TSH-R germline mutations, ranging from only slightly enlarged diffuse to multinodular goiters, suggest that additional mechanisms may be effective in the pathogenesis of toxic adenomas. 8626855 1996
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE The oncogenic potential of a novel somatic mutant TSHR delta 619 identified in a hyperfunctioning adenoma in this study is at present uncertain because of its intact function. 7673402 1995
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 AlteredExpression group BEFREE These data indicate that the VI transmembrane segment in the TSH receptor and presumably in the other G-protein coupled receptors is a critical domain for the activation of G-protein signalling and that the mutations described here may be the cause of the thyroid hyperfunctioning adenoma. 7566968 1995
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.400 GeneticVariation group BEFREE A point mutation in the third intracellular loop (codon 623) of the TSHR was found in 3 of 37 adenomas studied. 7714109 1995