Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE This unique disturbance of the cAMP-PDE pathway observed in the majority of <i>AIP</i>-mutation positive adenomas could contribute to their well-described poor response to somatostatin analogs and may support a role in tumorigenesis. 30941100 2019
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 AlteredExpression group BEFREE Altogether 13/56 (23%) adenomas had low AIP protein levels, and 14/56 (25%) low Ga<sub>i-2</sub> staining. 27998919 2017
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 AlteredExpression group BEFREE No significant difference was observed in AIP mRNA expression between tumors with low or high AIP protein expression suggesting post-transcriptional regulation. miR-34a was highly expressed in low AIP protein samples compared high AIP protein adenomas and miR-34a levels were inversely correlated with response to SSA therapy. miR-34a inhibited the luciferase-AIP-3'UTR construct, suggesting that miR-34a binds to AIP-3'UTR. 25658813 2015
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE AIP variants were detected in 3% of the 127 patients, comprising four of 48 patients with acromegaly (8%), 0 of 43 with prolactinomas, 0 of the 20 patients with non-functioning adenomas, 0 of 15 with corticotroph adenomas and 0 of one with a thyrotroph adenomas. 25184284 2014
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE AIP mutations are usually associated with somatotropinomas, but prolactinomas, nonfunctioning pituitary adenomas, Cushing disease, and other infrequent clinical adenoma types can also occur. 23371967 2013
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE AIP mutations cause a low penetrance autosomal dominant disease with often a distinct phenotype characterized by young-onset, aggressive, large GH, mixed GH and PRL or PRL-secreting adenomas. 23310926 2012
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 Biomarker group CTD_human Aryl-hydrocarbon receptor activity modulates prolactin expression in the pituitary. 22975028 2012
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE AIP mutations were detected in 16 (3.6%) of the 443 patients, comprising six of 148 patients with acromegaly (4.1%), six of 132 patients with prolactinomas (4.5%), one of 113 patients with nonfunctioning adenomas (0.9%), three of 44 patients with corticotropic adenomas (6.8%), and none of the six patients with thyrotropic adenomas. 22319033 2012
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE Patients with mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are characterized by young-onset somatotroph or lactotroph macroadenomas, while in the other, larger group of FIPA patients with typically adult-onset disease and more varied adenoma types, no causative gene(s) has been identified. 22612670 2012
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 Biomarker group BEFREE AIP immunostaining confirmed normal staining in the hyperplastic tissue and decreased staining in the adenoma in the tumors from both patients. 21450940 2011
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE In addition, we summarize the clinical features of IFS families with AIP mutations: The adenomas are diagnosed at a young age and are larger than in IFS patients without AIP mutations or in sporadic somatotropinomas, indicating more aggressive disease. 20616502 2010
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 AlteredExpression group BEFREE AIP sequence changes and expression were studied in FIPA and sporadic adenomas. 18381572 2008
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 GeneticVariation group BEFREE Though AIP mutation-positive individuals with prolactin-, mixed growth hormone/prolactin-, and ACTH-producing pituitary adenomas as well as non-secreting pituitary adenomas have been reported, most mutation-positive patients have had growth hormone-producing adenomas diagnosed at relatively young age. 17914118 2007
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 Biomarker group BEFREE Based on these results, we conclude that the loss of function of AIP contributes to IFS, but not for most Japanese sporadic GH-secreting adenomas. 17371465 2007
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.400 Biomarker group BEFREE Feasibility of AIP immunohistochemistry (IHC) as a prescreening tool was tested in 50 adenomas: 12 AIP mutation-positive versus 38 mutation-negative pituitary tumors. 17360484 2007