×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
In southern Brazil, pediatric adrenocortical tumor is a sentinel cancer for detecting families with germline p.R337H mutation in TP53 gene.
28864397
2018
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
We report a 9-month-old male who was diagnosed with an adrenocortical tumor and later found to harbor a novel TP53 c.559 G > C germline variant, resulting in p.Gly187Arg .
30239254
2018
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
Acquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypes.
22589739
2012
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
The high frequency of TP53 R337H carriers in southern Brazil is responsible for the highest known incidence of childhood adrenocortical tumor (ACT ).
22056871
2012
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
Our findings highlight the clinical and genetic counseling dilemmas that arise when an inherited TP53 mutation is found in a child with ACT without relatives with Li-Fraumeni-component tumors.
20967502
2011
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
A unique correlation between a single TP53 mutation (R337H ) and ACT has been reported in southern Brazilian children.
17427234
2008
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
Biomarker
group
LHGDN
Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity.
17289876
2007
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
LHGDN
The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients.
16786124
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
An inherited germline mutation in the p53 gene (TP53 R337H ) is detected in virtually all children with ACT in this region and accounts for the excess cases observed.
16200634
2006
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
GeneticVariation
group
BEFREE
Inheritance of R337H p53 gene mutation in children with sporadic adrenocortical tumor .
15952083
2005
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
Biomarker
group
HPO
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.500
CausalMutation
group
CGI