Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE ABSTRACT: Background The BCR-ABL-negative myeloproliferative neoplasms, i.e., polycythemia vera, essential thrombocythemia (ET), and myelofibrosis (MF), are characterized by mutations in JAK2, CALR, or MPL. 30889303 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The ROC curve analysis showed that a level of WT1 transcript >10 WT1 copies/10<sup>4</sup>ABL1 enabled the diagnosis of PMF with a specificity of 95.8% (PMF vs ET; ROC AUC = 0.91). 30612065 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE After 5 months, BCR-ABL fusion signals decreased to 5%, and myelofibrosis improved from MF Grade 2 to 1; she then underwent allogeneic bone marrow transplantation from an unrelated donor. 30879266 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE As the second most common mutation in BCR/ABL-negative MPNs, CALR mutation has been included in the latest World Health Organization (WHO) classification criteria as one of the main diagnostic criteria for both essential thrombocythemia (ET) and PMF. 29560522 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Myelofibrosis (MF) is a clinical manifestation of chronic BCR-ABL1-negative chronic myeloproliferative neoplasms. 29562644 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Primary myelofibrosis (PMF) is one of the classic BCR-ABL1 negative myeloproliferative neoplasms (MPN). 29256926 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia. 27539616 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Genetic lesions such as JAK2 mutations and BCR-ABL translocation are often mutually exclusive in MPN patients and lead to essential thrombocythemia, polycythemia vera, or myelofibrosis or chronic myeloid leukemia, respectively. 28335073 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Clonal hematologic diseases of the blood such as polycythemia vera, essential thrombocythemia and primary myelofibrosis belong to the BCR-ABL negative Myeloproliferative Neoplasms (MPN). 28914569 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR-ABL1-negative MPN is a subcategory that includes primary myelofibrosis (MF), post-essential thrombocythemia MF, and post-polycythemia vera MF. 28499938 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET). 29134817 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Myelofibrosis is a BCR-ABL-negative myeloproliferative neoplasm characterized by abnormal hematopoiesis. 27672139 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE BCR-ABL1-negative myeloproliferative neoplasms (MPNs) are clonal stem cell disorders defined by proliferation of one or more myeloid lineages, and carry an increased risk of vascular events and progression to myelofibrosis and leukemia. 28543980 2017
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE In 1960, Nowell and Hungerford discovered an invariable association between the Philadelphia chromosome (subsequently shown to harbor the causal BCR-ABL1 mutation) and CML; accordingly, the term MPN is primarily reserved for PV, ET, and PMF, although it includes other related clinicopathologic entities, according to the World Health Organization (WHO) classification system. 26492355 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The classic BCR-ABL1-negative myeloproliferative neoplasm is an operational sub-category of MPNs that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). 27039813 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Myelofibrosis (MF) and polycythemia vera (PV) are BCR-ABL1-negative myeloproliferative neoplasms associated with somatic hematopoietic stem cell mutations leading to over activation of JAK-STAT signaling. 27017614 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Primary myelofibrosis (PMF) is a rare chronic BCR-ABL1-negative myeloproliferative neoplasm characterized by progressive bone marrow fibrosis, inefficient hematopoiesis, and shortened survival. 27756071 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The classical BCR-ABL1-negative myeloproliferative neoplasms (MPN) include essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF). 26933174 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Myelofibrosis (MF) is a BCR-ABL-negative myeloproliferative neoplasm characterized by anemia, splenomegaly, debilitating constitutional symptoms, and shortened survival. 26181658 2015
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) constitute the BCR-ABL1-negative myeloproliferative neoplasms and are characterized by mutually exclusive Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) mutations; respective frequencies of these mutations are approximately 95%, 0%, and 0% in PV, 60%, 20%, and 3% in ET, and 60%, 25%, and 7% in PMF. 26182311 2015
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE The diagnosis of the BCR-ABL-negative myeloproliferative neoplasms (MPN), namely polycythemia vera, essential thombocythemia and primary myelofibrosis has relied significantly on the detection of known causative mutations in the JAK2 or MPL genes, which account for the majority of MPN patients. 25349114 2015
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE Polycythaemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (MF), are the most common myeloproliferative neoplasms (MPN) in patients without the BCR-ABL1 gene rearrangement. 23986553 2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. 25232060 2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 Biomarker disease BEFREE Is there a role for JAK inhibitors in BCR-ABL1-negative myeloproliferative neoplasms other than myelofibrosis? 25520049 2014
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.100 GeneticVariation disease BEFREE The clonal blood disorders polycythemia vera, essential thrombocythemia and primary myelofibrosis belong to the BCR-ABL1-negative myeloproliferative neoplasms and are specified by increased production of terminally differentiated myeloid cells. 24190690 2013