Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 AlteredExpression disease BEFREE This trafficking pattern could not be attributed to discordant expression of integrins or chemokine receptors other than the downregulation of C-X-C chemokine receptor type 4 by both PB and splenic MF CD34(+) cells. 25461253 2015
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 Biomarker disease BEFREE The in vitro treatment of splenic and peripheral blood MF CD34(+) cells with the JAK1/2/3 inhibitor, AZD1480, reduced the absolute number of CD34(+), CD34(+)CD90(+), and CD34(+)CXCR4(+) cells as well as assayable hematopoietic progenitor cells (HPCs) irrespective of the JAK2 and calreticulin mutational status. 25193869 2014
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 Biomarker disease BEFREE Treatment of PMF CD34(+) cells with chromatin-modifying agents (CMAs) but not hydroxyurea, Janus kinase 2 (JAK2) inhibitors, or low doses of interferon-α led to the generation of greater numbers of CD34(+) chemokine (C-X-C motif) receptor (CXCR)4(+) cells, which were capable of migrating in response to chemokine (C-X-C motif) ligand (CXCL)12 and resulted in a reduction in the proportion of hematopoietic progenitor cells (HPCs) that were JAK2V617F(+). 20858855 2010
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 Biomarker disease BEFREE Similar abnormalities in the SDF-1/CXCR4 axis are observed in PMF patients and in the Gata1 low mice model of myelofibrosis. 18206727 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 Biomarker disease LHGDN Similar abnormalities in the SDF-1/CXCR4 axis are observed in PMF patients and in the Gata1 low mice model of myelofibrosis. 18206727 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 PosttranslationalModification disease LHGDN These data point to abnormal methylation of the CXCR4 promoter as a mechanism contributing to constitutive migration of CD34(+) cells in PMF. 18511598 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 PosttranslationalModification disease BEFREE These data point to abnormal methylation of the CXCR4 promoter as a mechanism contributing to constitutive migration of CD34(+) cells in PMF. 18511598 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 GeneticVariation disease BEFREE Abnormal expression of HMGA2 and CXCR4 in IM granulocytes was dependent on the presence and the mutational status of JAK2(V617F) mutation. 16990584 2007
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.070 AlteredExpression disease LHGDN CXCR4 down-regulation was associated with advanced patient age, the presence of severe anemia, thrombocytopenia, and degree of bone marrow fibrosis. 17350297 2007