Gene: HLA-B ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 Biomarker disease BEFREE ATD-induced agranulocytosis was associated with HLA-B*27:05 (OR 10.97; 95% CI 0.75-159.99), HLA-B*38:02 (OR 19.85; 95% CI 7.94-49.57) and HLA-DRB1*08:03 (OR 5.29; 95% CI 3.44-8.14). 31108563 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 GeneticVariation disease BEFREE The human leukocyte antigen (HLA) region has been associated with genetic susceptibility to clozapine-induced agranulocytosis (single amino acid changes in HLA-DQB1 (126Q) and HLA-B (158T)). 29298994 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 GeneticVariation disease BEFREE All subjects carrying the HLA-B*27:05 allele had agranulocytosis. 28931918 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 GeneticVariation disease BEFREE Agranulocytosis induced by non-chemotherapy drugs in general was significantly associated with the HLA region on chromosome 6, with odds ratios (ORs) of 3·24 (95% CI 2·31-4·55, p=1·20 × 10(-11)) for HLA-B*27:05 and 3·57 (2·61-4·90, p=2·32 × 10(-15)) for the top SNP (rs114291795). 27157822 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 Biomarker disease BEFREE The positive and negative predictive values of HLA-B*38:02:01 in predicting CMZ/MMI-induced agranulocytosis were 0.07 and 0.999. 26599303 2016
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 GeneticVariation disease BEFREE Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. 25187353 2014
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B 		0.070 GeneticVariation disease BEFREE HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis. 7961560 1994