Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Biomarker disease BEFREE This meta-analysis aimed to assess the clinical effects of G-CSF and non-G-CSF on recovery duration in patients with ATD-induced agranulocytosis by analyzing the overall clinical outcomes. 31824417 2019
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Biomarker disease BEFREE One had an autoimmune lymphoproliferative syndrome causing chronic agranulocytosis requiring granulocyte colony-stimulating factor injection. 29107664 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Biomarker disease BEFREE Agranulocytosis was treated with 8 doses of G-CSF with full recovery. 29181135 2017
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Biomarker disease BEFREE Granulocytopenia was associated with impaired host defense and increased susceptibility to Escherichia coli K1 and Klebsiella pneumoniae sepsis in antibiotic-treated neonates, which could be partially reversed by administration of G-CSF. 24747744 2014
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Therapeutic disease CTD_human [Dapsone-induced agranulocytosis. The role of xenobiotic-metabolizing enzymes demonstrated by a case report]. 15999287 2005
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 AlteredExpression disease BEFREE G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia. 9322685 1997
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.360 Biomarker disease BEFREE Human granulocyte colony-stimulating factor produced by Escherichia coli shortens the period of granulocytopenia induced by irradiation in mice. 3115920 1987
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
0.330 Biomarker disease BEFREE The reduction of the clozapine nitrenium ion supports association studies showing that NQO2 is a genetic risk factor for clozapine-induced agranulocytosis. 29281794 2018
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
0.330 Biomarker disease BEFREE NQO2 1541AA (NRH quinone oxidoreductase 2; protects cells against oxidative metabolites) was present at a higher frequency in agranulocytosis patients compared with control (23% versus 7%, P=0.03), as was ABCB1 (ABC-transporter-B1; drug efflux transporter) 3435TT (32% versus 20%, P=0.05). 27168101 2017
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
0.330 Biomarker disease CTD_human Such a reduction in message suggests that the NQO2 gene may be involved in the development of clozapine-induced AGR. 14617031 2003
Entrez Id: 4835
Gene Symbol: NQO2
NQO2
0.330 Biomarker disease BEFREE Such a reduction in message suggests that the NQO2 gene may be involved in the development of clozapine-induced AGR. 14617031 2003
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.310 Biomarker disease CTD_human Full-dose CHOP chemotherapy combined with granulocyte colony-stimulating factor for aggressive non-Hodgkin's lymphoma in elderly patients: a prospective study. 11732872 2001
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.310 Biomarker disease CTD_human With GM-CSF starting on day 1, dose-limiting granulocytopenia occurred during cycle no. 8120554 1994
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.310 Biomarker disease BEFREE These data suggest that GM-CSF may be a therapeutic option in some patients with LGLP complicated by granulocytopenia and/or infection. 1511064 1992
Entrez Id: 6948
Gene Symbol: TCN2
TCN2
0.300 Biomarker disease GENOMICS_ENGLAND TC II deficiency: avoidance of false-negative molecular genetics by RNA-based investigations. 19373259 2009
Entrez Id: 2672
Gene Symbol: GFI1
GFI1
0.200 Biomarker disease MGD
Entrez Id: 201294
Gene Symbol: UNC13D
UNC13D
0.100 Biomarker disease HPO
Entrez Id: 10525
Gene Symbol: HYOU1
HYOU1
0.100 Biomarker disease HPO
Entrez Id: 6901
Gene Symbol: TAZ
TAZ
0.100 Biomarker disease HPO
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.100 Biomarker disease HPO
Entrez Id: 6234
Gene Symbol: RPS28
RPS28
0.100 Biomarker disease HPO
Entrez Id: 23451
Gene Symbol: SF3B1
SF3B1
0.100 Biomarker disease HPO
Entrez Id: 6141
Gene Symbol: RPL18
RPL18
0.100 Biomarker disease HPO
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.070 Biomarker disease BEFREE ATD-induced agranulocytosis was associated with HLA-B*27:05 (OR 10.97; 95% CI 0.75-159.99), HLA-B*38:02 (OR 19.85; 95% CI 7.94-49.57) and HLA-DRB1*08:03 (OR 5.29; 95% CI 3.44-8.14). 31108563 2019
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.070 GeneticVariation disease BEFREE The human leukocyte antigen (HLA) region has been associated with genetic susceptibility to clozapine-induced agranulocytosis (single amino acid changes in HLA-DQB1 (126Q) and HLA-B (158T)). 29298994 2019