Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Histopathologically, the alkaloidal fraction-treated 3xTg-AD mice exhibited a significant reduction in tauopathy and astrogliosis, as well as a significant decrease in the proinflammatory marker COX-2 and an increase in pAkt. 30530228 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE The great interest of the researchers in this field is due to the importance of selective COX-2 inhibitors as a relatively safe and effective set of compounds which could present different properties such as antirheumatic, anti-inflammatory, antiplatelet, anti-Alzheimer's disease, anti-Parkinson's disease, and anticancer. 31132889 2019
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE It has been reported that inhibition of COX-2 beside traditional effects of NSAIDs, reduces the risk of colorectal, breast and lung cancers and also slow the progress of Alzheimer's disease.Zarghi et al. reported 8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 102) as a novel compound with similar IC50 to celecoxib besides improved selectivity index (COX-1/COX-2 inhibitory potency) in comparison with celecoxib. 28979299 2017
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells. 24621265 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE This study shows that 24-hydroxycholesterol, 27-hydroxycholesterol, and 7β-hydroxycholesterol, the three oxysterols potentially implicated in AD pathogenesis, induce some pro-inflammatory mediator expression in human neuroblastoma SH-SY5Y cells, via Toll-like receptor-4/cyclooxygenase-2/membrane bound prostaglandin E synthase (TLR4/COX-2/mPGES-1); this clearly indicates that oxysterols may promote neuroinflammatory changes in AD. 24802026 2014
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE COX-2 -1195AA carriers showed a one-third lower risk of developing AD as compared to those with -1195GG and GA genotypes (OR = 0.3, 95 % CI 0.194-0.465, P = 0.000). 22622868 2013
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Both cannabinoids were effective at reducing the enhancement of COX-2 protein levels and TNF-α mRNA expression found in the AD model. 22248049 2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE As NSAIDs inhibit the enzymatic activity of the inflammatory cyclooxygenases COX-1 and COX-2, these findings suggest that downstream prostaglandin signaling pathways function in the preclinical development of AD. 22915243 2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE Our data suggest that these alleles of COX-2 and 5-LO could be risk factors for AD. 20110601 2010
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Enhanced COX-2 expression had been found in regions of brains from patients with Alzheimer's disease (AD). 17234302 2008
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Moreover, the induction of COX-2 and the generation of PGs has been linked to neuroinflammatory aspects of Alzheimer's disease (AD). 16546299 2006
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 GeneticVariation disease BEFREE This study demonstrates for the first time that COX-2 may be a downstream effector of mutant N141I PS2-mediated apoptotic cell death and that inhibition of COX-2 may neuroprotect in AD through modulation of a GSK-3beta-beta-catenin-mediated response. 16331303 2006
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE The results indicate that while COX-2 remains a major player in propagating inflammmation in AD and in stressed HN cells, COX-3 may play ancillary roles in membrane-based COX signaling or when basal levels of COX-1 or COX-2 expression persist. 15453269 2004
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE We concluded that 1) Tg mice showed a behavioral dysfunction in the water maze test, 2) levels of hPS2, Abeta-42, caspase-3, and Cox-2 expression were modulated in the brains of both Tg mice, 3) dense staining with antibody to hPS2, Abeta-42, caspase-3, and Cox-2 was visible in the brains of Tg mice compared with age-matched control mice, and 4) distinguishable AD phenotypes between hPS2w- and hPS2m-Tg mice did not appear. 12039862 2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Based on our findings, it is unlikely that neuronal COX-2 contributes to pathology in end stage AD; however, COX-2 in other cell types may participate in the inflammation-related response associated with the disease. 11754989 2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Because there is extensive evidence that C1q and other complement components are involved in Alzheimer's disease (AD) neurodegeneration, this study advances our understanding of the apparent benefits of COX-2 inhibition in AD. 11810182 2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE Moreover, the expression of both COX-2 and PLA2 appears to be strongly activated during Alzheimer's disease (AD), indicating the importance of inflammatory gene pathways as a response to brain injury. 12432919 2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE The data indicates that COX-2 overexpression causes alteration of neuronal cell cycle in a murine model of AD neuropathology, and provides a rational basis for targeting neuronal COX-2 in therapeutic research aimed at slowing the clinical progression of AD. 11959394 2002
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE COX-2 mRNA levels in AD, PD, cerebrovascular disease, and control cases were each significantly lower than in ALS and were not significantly different from each other. 11571316 2001
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Because the inhibition of COX-1 is also known to cause tissue damage in the gastrointestinal system from the resultant reduced cytoprotection, selective COX-2 inhibitors are being investigated and tested clinically as potentially better therapeutics for AD patients. 10877525 2000
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE Since APP holoprotein can be amyloidogenic, while APPs may be neurotrophic, our findings suggest that some neuroimmunophilin ligands, NSAIDs and COX-2 inhibitors might suppress amyloid formation and enhance neuronal regeneration in Alzheimer's disease. 11193162 2000
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 AlteredExpression disease BEFREE The ability of p38 MAPK to augment COX-2 expression in human neuroblastoma cells, as shown here, suggests that p38 MAPK may be involved in neuronal expression of COX-2 in AD. 11032891 2000
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE These data suggest that basic gene induction mechanisms, which have been conserved over long periods of evolution, that increase NF-kappaB-DNA binds ing may be fundamental in driving transcription from inflammation-related genes, such as COX-2, that operate in stressed tissues, in normally aging cell lines, and in neurodegenerative disorders that include AD brain. 9726429 1998
Entrez Id: 107075310
Gene Symbol: MTCO2P12
MTCO2P12
0.100 Biomarker disease BEFREE COX-2 RNA message was found to be degraded at similar rates in both control and AD tissues, and a strong positive correlation between the PMI and the intensity of the COX-2 RNA signal was noted (ANOVA = 0.006). 9452008 1997