Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | disease | BEFREE | Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer's Disease. | 30963972 | 2019 | ||||
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0.080 | Biomarker | disease | BEFREE | Understanding the role of calcium channels and GPCRs to maintain calcium homeostasis is an attempt to develop effective AD treatments. | 31655116 | 2019 | ||||
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0.080 | Biomarker | disease | BEFREE | We present here for the first time a study analyzing the prevalence of GPCR-AABs in patients with different dementia forms such as unclassified, Lewy body, vascular and Alzheimer's dementia. | 29538413 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, there is still a lack of insight into the mechanistic link between GPCR-mediated microglial activation and its pathological consequences in AD. | 30186116 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Collectively, these studies identify β-arrestin 2 as a new therapeutic target for reducing amyloid pathology and GPCR dysfunction in Alzheimer's disease. | 23202293 | 2013 | ||||
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0.080 | Biomarker | disease | BEFREE | In conclusion, interference with the p60TRP/ GPCR/secretase signalling pathway might be a new therapeutic target for the treatment of Alzheimer's disease (AD). | 21199326 | 2011 | ||||
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0.080 | Biomarker | disease | BEFREE | The chemotactic G-protein-coupled receptor (GPCR) formyl-peptide-receptor like-1 (FPRL1) plays an essential role in the inflammatory responses of host defence mechanisms and neurodegenerative disorders such as Alzheimer's disease (AD). | 21299846 | 2011 | ||||
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0.080 | Biomarker | disease | BEFREE | Our study not only uncovers a molecular mechanism for the formation of a DOR/secretase complex that regulates the specificity of secretase for Abeta production but also suggests that intervention of either formation or trafficking of the GPCR/secretase complex could lead to a new strategy against AD, potentially with fewer side effects. | 20066010 | 2010 |