Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE Our results reveal CD2AP neuronal requirements with relevance to AD susceptibility, including for proteostasis, calcium handling, and synaptic structure and function. 31412248 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE The recent evidence concerning the roles of CD2AP in the AD pathogenesis is summarized and CD2AP can be a promising therapeutic target for AD. 31440393 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE Taken together, these results may explain why impaired CD2AP function is a risk factor for AD. 31138646 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE Genetic variants in PICALM, BIN1, CD2AP, and RIN3 are associated with increased risk of Alzheimer's disease, all dementia, and suggested vascular dementia independent of the strong APOE ε4 allele. 30830563 2019
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease CTD_human Three new AD susceptibility loci, INPP5D, CD2AP, and CASS4, showed specific association with CSF tau biomarkers. 30320580 2018
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Decreased gene expression of CD2AP in Chinese patients with sporadic Alzheimer's disease. 28392172 2017
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. 28199971 2017
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE To examine whether there is a genetic link for these diseases, we performed a case-control study in Chinese population to evaluate the association of AD genome-wide association studies top hits with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, and CD2AP). 26724962 2016
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE We have used exome and genome sequencing data to analyze the single independent and joint effect of rare and low-frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly controls of British and North-American ancestry. 27289440 2016
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Our analysis further supports previous findings that the CD2AP rs9349407 polymorphism contributes to AD susceptibility. 25092125 2015
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE In humans, CD2AP AD susceptibility locus (rs9349407) is associated with an increased plaque burden. 25887956 2015
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Our screen implicates cindr, the fly ortholog of the human CD2AP AD susceptibility gene, as a modulator of Tau-mediated disease mechanisms. 24067533 2014
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE This article reviews possible links between AD pathogenic factors such as AβPP/Aβ and tau; novel risk genes including clusterin, phosphatidylinositol-binding clathrin assembly protein, complement receptor 1, bridging integrator 1, ATP-binding cassette transporter 7, membrane-spanning 4-domains subfamily A, CD2-associated protein, sialic acid-binding immunoglobulin-like lectin, and ephrin receptor A1; metabolic changes including insulin resistance and hypercholesterolemia; lipid changes including alterations in brain phospholipids, cholesterol and ceramides; glial changes affecting microglia and astrocytes; alterations in brain iron metallome and oxidative stress; and slow excitotoxicity. 23481689 2013
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Besides the previously reported APOE and CR1 loci, we found that the ABCA7 (rs3764650; P = .02) and CD2AP (rs9349407; P = .03) AD susceptibility loci are associated with neuritic plaque burden. 23836404 2013
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASDB Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU, CR1, PICALM, BIN1, ABCA7, MS4A gene cluster, CD2AP, CD33, and EPHA1). 23232270 2013
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASCAT Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2013
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease BEFREE The study prioritized new AD-associated biological mechanisms and focused the analysis on previously unreported interactions associated with the biological processes of polymorphisms that affect specific protein domains within characterized AD genes and their direct interactors using (1) concordant GO-BP and (2) domain interactions within STRING protein-protein interactions corresponding to the genomic location of the AD polymorphism (eg, EPHA1, APOE, and CD2AP). 22319180 2012
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease BEFREE Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. 21460840 2011
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease CTD_human Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 GeneticVariation disease GWASCAT Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
0.500 Biomarker disease CTD_human Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. 21460840 2011