Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 AlteredExpression disease BEFREE Our results demonstrate altered active IGF1 and IGF1R levels in AD hippocampi, and suggest that boosting brain expression of IGF1 may comprise an approach to prevent neuronal damage and memory loss in AD. 31760608 2020
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 AlteredExpression disease BEFREE These findings suggest that activation of IGF1R/CaMKIV/HAT/BDNF signaling by gestational environment enrichment may serve as a promising strategy to delay AD progression. 30867903 2019
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 Biomarker disease BEFREE Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer's Disease. 30809143 2019
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 AlteredExpression disease BEFREE Moreover, in Alzheimer's disease neurons, a high proportion of genes responding to Alzheimer's disease showed a reversed differential expression when IGF1R was deleted. 28595357 2017
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 AlteredExpression disease BEFREE But exclusively decreased IGF-1R expression reduces AD-associated mortality independent of β-amyloid accumulation and FoxO1-mediated transcription. 22057897 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 Therapeutic disease RGD Xanthoceraside attenuates learning and memory deficits via improving insulin signaling in STZ-induced AD rats. 23562514 2013
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 Biomarker disease RGD While these disturbances were mostly corrected by restoring receptor function, blockade of the IGF-I receptor exacerbated AD-like pathology in old mutant mice already affected of brain amyloidosis and cognitive derangement. 16274856 2006
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 Biomarker disease CTD_human Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? 15750215 2005
Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
0.560 Biomarker disease BEFREE Further studies demonstrated that: 1) ChAT expression increases with insulin or IGF-I stimulation; 2) ChAT is expressed in insulin and IGF-I receptor-positive cortical neurons; and 3) ChAT co-localization in insulin or IGF-I receptor-positive neurons is reduced in AD. 16340083 2005