Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE The current study was designed to investigate which of the inflammasome complexes are critical for IL-1β production in AD. 31715312 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE In the current study, we determined the effects of Ampelopsin (AMP) on the levels of proinflammatory cytokines (PICs, IL-1β, IL-6 and TNF-α), and products of oxidative stress 8-isoprostaglandin F2α (8-iso PGF2α, a product of oxidative stress); and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a key biomarker of protein oxidation) in the hippocampus using a rat model of AD. 31797758 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain. 31535638 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE In the current report, we determined the effects of microRNA-155 (miR-155) on the levels of IL-1β, IL-6 and TNF-α, and their respective receptors in the hippocampus using a rat model of AD. 31456514 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE CCH strongly enhanced NLRP3, activated caspase-1 and IL-1β expressions in hippocampus and thalamus at age 12 M of AD mice. 29885344 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE A total of 170 studies were included in the meta-analysis and systematic review, which demonstrated increased peripheral levels of high-sensitivity C reactive protein (Hedges's g 0.281, p<0.05), interleukin-6 (IL-6) (0.429, p<0.005), soluble tumour necrosis factor receptor 1 (sTNFR1) (0.763, p<0.05), soluble tumour necrosis factor receptor 2 (sTNFR2) (0.354, p<0.005), alpha1-antichymotrypsin (α1-ACT) (1.217, p<0.005), IL-1β (0.615, p<0.05) and soluble CD40 ligand (0.868, p<0.005), and CSF levels of IL-10 (0.434, p<0.05), monocyte chemoattractant protein-1 (MCP-1) (0.798, p<0.005), transforming growth factor-beta 1 (1.009, p<0.05), soluble triggering receptor expressed on myeloid cells2 (sTREM2) (0.587, p<0.001), YKL-40 (0.849, p<0.001), α1-ACT (0.638, p<0.001), nerve growth factor (5.475, p<0.005) and visinin-like protein-1 (VILIP-1) (0.677, p<0.005), in AD compared with the control. 30630955 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Moreover, apelin-13 inhibited microglia and astrocyte activation, reduced IL-1β and TNF-α expression and hippocampal BDNF/TrkB expression deficit in AD rats. 31040784 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE This study measured amyloid-beta (Aβ), interleukin-1 beta (IL-1β), and glial fibrillary acidic protein (GFAP) expression in the hippocampus of Alzheimer's disease (AD) rat models to elucidate the mechanism of anti-inflammatory effect of ginsenoside Rb1 in AD. 31217866 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Furthermore, THS reduced mRNA expression of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β and increased synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus of AD mice. 31244052 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The db mutation also reduced the cortical IL-1β mRNA level and IBA1 protein level in young AD mice, with no significant effect on the activation of microglia and astrocytes. 31034991 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). 31570577 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE In the AD model group, the inhibition of PC12 cell growth was significantly increased, and the mRNA expression levels of IL‑1β, IL‑6, TNF‑α and MIF were also increased. 31322215 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Increased expression of IL-1β and iron accumulation have been identified in microglial cells that cluster around amyloid plaques in AD mouse models and post-mortem brain tissues of AD patients. 31693761 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Our data showed that SEO improved the cognitive ability of mice with Aβ<sub>1-42</sub> or lipopolysaccharides (LPS)-induced Alzheimer's disease (AD) and suppressed the production of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the hippocampus. 31463498 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Further, a significant increased expression of cleaved caspase-1 and IL-1β, the products of inflammasome activation, was detected in the cortex of AD brains. 30741672 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE However, the lack of P2X7R did not significantly affect the release of IL-1β or the levels of non-amyloidogenic fragment, sAPPα, in AD mice. 29934546 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Increased concentrations of interleukin 1 (IL-1) in the cerebrospinal fluid and serum of patients with Alzheimer disease (AD) reduced phagocytic capacity point to an inflammatory activation of mononuclear phagocytes in AD. 31018751 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Compared with controls, IL-1β (pooled SMD: 1.37, 95% CI: 0.06-2.68, significant heterogeneity: I<sup>2</sup> = 96.01%) was significantly elevated in Alzheimer's disease. 30104698 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Importantly, CTSB activity, IL-1β levels and malondialdehyde (MDA) were remarkably elevated in plasma of AD patients compared to healthy controls, while glutathione was significantly lower than healthy controls. 29196167 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer's disease. 29712570 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE The results showed that the hippocampal and serum levels of ROS, nitrite, TNF-α, and IL-1β were significantly higher in the AD animals along with increased chromatolysis and impairments of memory. 30377887 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Our findings support the clinical development of Mcc950 and clinically available IL-1- and TNF-α-neutralizing agents in early AD. 29477641 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 GeneticVariation disease BEFREE Increased inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1 β), and tumor necrosis factor-α (TNF-α) are associated with Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). 28856541 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 Biomarker disease BEFREE Here we studied the effect of amyloid beta-peptides (Aβ), interleukin 1-beta (IL-1β), and CSF from AD, Lewy body dementia (LBD) or subjective cognitive impairment (SCI) patients on the NGF overproducing cell line NGC-0295. 30092220 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.600 AlteredExpression disease BEFREE Circulating levels of IL-1 family cytokines and receptors in Alzheimer's disease: new markers of disease progression? 30541566 2018