Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE The results provide the first evidence that the miR-134-mediated post-transcriptional regulation of CREB-1 and BDNF is an important molecular mechanism underlying the plasticity deficit in AD; thus demonstrating the critical role of miR-134-5p as a potential therapeutic target for restoring plasticity in AD condition. 31625272 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE These results suggested that AD or MCI is accompanied by reduction of peripheral BDNF, but the levels of circulating BDNF may not be suitable as a diagnostic marker for AD and MCI. 31518516 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Injection of L-T4 (10 μg/kg) alleviated memory deficits and also improved factors of oxidative stress and BDNF level in the STZ-induced AD rats. 29927658 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE The degeneration of cholinergic basal forebrain (cBF) neurons in Alzheimer's disease (AD) leads to the cognitive impairment associated with this condition. cBF neurons express the p75 neurotrophin receptor (p75<sup>NTR</sup>), which mediates cell death, and the extracellular domain of p75<sup>NTR</sup> can bind to amyloid beta (Aβ) and promote its degradation. 30374941 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE These data support a complex genetic interaction at loci encoding proteins implicated in the DBH-BDNF inflammatory pathway that modifies AD risk, particularly in women. 30909233 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE 7,8-Dihydroxyflavone (7,8-DHF), as a high-affinity TrkB receptor agonist, has been extensively explored in many human disorders involving brain-derived neurotrophic factor (BDNF) such as Alzheimer's disease, Parkinson's disease, depression, and obesity. 31384856 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE In Alzheimer's disease (AD), a single-nucleotide polymorphism in the gene encoding brain-derived neurotrophic factor (BDNF<sub>Val66Met</sub>) is associated with worse impact of primary AD pathology (beta-amyloid, Aβ) on neurodegeneration and cognitive decline, rendering BDNF<sub>Val66Met</sub> an important modulating factor of cognitive impairment in AD. 30899092 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Results indicate that BDNF and TrkB dysregulation contribute to AD neuropathology, most notably hippocampal NPs and NFTs. 31349032 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Further, gradual dysregulation of neurotrophic factors like NGF and brain derived neurotrophic factor (BDNF) have been reported during AD development thus intensifying further research in targeting these factors as disease modifying therapies against AD. 30804738 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE The beneficial effects of conditional BDNF production and local delivery at the location of active neuropathology highlight the potential to use endogenous biomarkers with early onset, such as astrogliosis, as regulators of neurotrophic therapy in AD.<b>SIGNIFICANCE STATEMENT</b> Recent evidence places astrocytes as pivotal players during synaptic plasticity and memory processes. 30700530 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE p75 neurotrophin receptor (p75<sup>NTR</sup>) has been implicated in Alzheimer's disease (AD). 31479419 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Here, we show that total sulfated GAGs from hippocampus of Alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including FGF-2, VEGF, and BDNF while their capacity to bind to tau is remarkable increased. 30608949 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Additionally, there were no significant differences in serum BDNF levels between patients with AD and MCI (eight studies, <i>n</i> = 906) and between MCI and HC (nine studies, <i>n</i> = 5090). 30634650 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Transplantation of BDNF modified hUC-MSCs-derived cholinergic-like neurons significantly improved spatial learning and memory abilities in the AD rats, increased the release of acetylcholine and ChAT expression in the hippocampus, enhanced the activation of astrocytes and microglia, reduced the expression of Aβ and recombinant human beta-site APP-cleaving enzyme1 (BACE1), inhibited neuronal apoptosis, and promoted neurogenesis. 30586546 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease. 30810826 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Thus, our findings support that BDNF reduction mediates Tau pathology via activating δ-secretase in AD. 31004063 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE BDNF total long 3' transcript expression was significantly lower in those with early AD neuropathology, compared to those without any neuropathology (p = 0.021). 31127785 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE GQ1b-infused 3xTg-AD mice had substantially increased BDNF levels compared with artificial cerebrospinal fluid (aCSF)-treated 3xTg-AD mice. 31186474 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease. 28888073 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer's Disease. 31256135 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE These findings indicate that physical exercise has the potential to prevent the occurrence of early emotional disturbances associated with AD and this appears to be mediated, at least in part, by modulation of hippocampal BDNF and mTOR signaling as well as through promotion of cell proliferation and survival in the hippocampal DG. 31078612 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 GeneticVariation disease BEFREE Brain-derived neurotrophic factor (BDNF) is associated with onset of several central nervous system disorders, e.g., Parkinson's disease, Alzheimer's disease, depression, epilepsy, and chronic pain. 31195342 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 AlteredExpression disease BEFREE Alzheimer's disease is marked by the presence of amyloid-beta (Aβ) plaques, elevated central cytokine levels, dysregulation of BDNF-related gene expression, and cognitive decline. 30031883 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.600 Biomarker disease BEFREE Protein-protein interaction (PPI) analysis revealed SERPINA3 and BDNF to possess high node degree interaction with literature derived candidate genes (LDGs) in AD males and females, respectively, thus were selected as potential AD targets. 31543038 2019