Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.010 Biomarker disease BEFREE We utilized 18-month-old endothelial nitric oxide synthase (eNOS) heterozygous knockout (<sup>+/-</sup>) mice, a clinically relevant model of endothelial dysfunction, to examine the role of endothelial nitric oxide (NO) in vascular accumulation. eNOS<sup>+/-</sup> mice had significantly higher vascular levels of Aβ40 ( P < 0.05).Aβ42 was not detected. 30614363 2020
Entrez Id: 9332
Gene Symbol: CD163
CD163
0.010 Biomarker disease BEFREE CD36, scavenger receptor class A member 1, triggering receptor expressed on myeloid cells 2, CD163; P < 0.05-0.0001), endosomal processing (P < 0.05-0.0001), and ∼80% increased extracellular degradation of amyloid-β1-42 (P < 0.001). 31794021 2020
Entrez Id: 54210
Gene Symbol: TREM1
TREM1
0.010 GeneticVariation disease BEFREE This study demonstrated an association between TREM1 variant rs2234246 and brain amyloidosis. 31721052 2020
Entrez Id: 2931
Gene Symbol: GSK3A
GSK3A
0.010 Biomarker disease BEFREE Emerging evidence suggests important and specific roles for GSK-3α in fatty acid accumulation, insulin resistance, amyloid-β-protein precursor metabolism, atherosclerosis, cardiomyopathy, fibrosis, aging, fertility, and in a variety of cancers. 31785335 2020
Entrez Id: 64399
Gene Symbol: HHIP
HHIP
0.010 Biomarker disease BEFREE We also found that diabetic rats expressing amyloid-forming human amylin in the pancreas (the HIP rat model) have increased tissue levels of hypoxia-inducible transcription factors, compared to diabetic rats that express non-amyloid forming rat amylin (the UCD rat model). 31739987 2020
Entrez Id: 5068
Gene Symbol: REG3A
REG3A
0.010 Biomarker disease BEFREE We also found that diabetic rats expressing amyloid-forming human amylin in the pancreas (the HIP rat model) have increased tissue levels of hypoxia-inducible transcription factors, compared to diabetic rats that express non-amyloid forming rat amylin (the UCD rat model). 31739987 2020
Entrez Id: 11202
Gene Symbol: KLK8
KLK8
0.010 Biomarker disease BEFREE Concomitant incubation of beta-amyloid ()-producing primary neurons with KLK8 and its inhibitory antibody increased neurite complexity and soma size. 31734318 2020
Entrez Id: 7942
Gene Symbol: TFEB
TFEB
0.010 Biomarker disease BEFREE At present, this article reviews this relationship from these aspects: (a) the signaling pathways of regulating autophagy; (b) the relationships between the autophagy and the processing of ; (c) and Tau cause autophagy dysfunction; (d) normal autophagy promotes the clearance of and Tau; (e) the relationships between the autophagy and both genes and proteins related to AD: TFEB, miRNAs, Beclin-1, Presenilin, and Nrf2; and (f) the small molecules regulating autophagy on AD therapy. 31503421 2020
Entrez Id: 6159
Gene Symbol: RPL29
RPL29
0.010 Biomarker disease BEFREE We also found that diabetic rats expressing amyloid-forming human amylin in the pancreas (the HIP rat model) have increased tissue levels of hypoxia-inducible transcription factors, compared to diabetic rats that express non-amyloid forming rat amylin (the UCD rat model). 31739987 2020
Entrez Id: 154091
Gene Symbol: SLC2A12
SLC2A12
0.010 AlteredExpression disease BEFREE In summary, increases GLUT12 protein expression in the brain pointing out a central role of the transporter in AD pathology and opening new perspectives for the treatment of this neurodegenerative disease. 31473905 2020
Entrez Id: 6767
Gene Symbol: ST13
ST13
0.010 Biomarker disease BEFREE We also found that diabetic rats expressing amyloid-forming human amylin in the pancreas (the HIP rat model) have increased tissue levels of hypoxia-inducible transcription factors, compared to diabetic rats that express non-amyloid forming rat amylin (the UCD rat model). 31739987 2020
Entrez Id: 6404
Gene Symbol: SELPLG
SELPLG
0.010 Biomarker disease BEFREE Close collaboration between the ophthalmologist and the internist will facilitate a more precise diagnosis of ocular involvement in amyloidosis and allow the multidisciplinary management of these patients.<b>Abbreviations:</b> CD: corneal dystrophy; CLA: corneal lattice amyloidosis; CNS: central nervous system; CT: computed tomography; FAP: familial amyloidotic polyneuropathy; GDLCD: gelatinous drop-like corneal dystrophy; GLN: gelsolin; LCD: lattice corneal dystrophy; MRI: magnetic resonance imaging; OLT: orthotopic liver transplantation; TEM: transmission electron microscopy; TGFBI: transforming growth factor β induced; TTR: transthyretin. 31829761 2020
Entrez Id: 410
Gene Symbol: ARSA
ARSA
0.010 Biomarker disease BEFREE The Cu<sup>2+</sup> chelating affinity was sufficient for EDTA-ASA to sequester Cu<sup>2+</sup> from -Cu (II) aggregates. 31786439 2020
Entrez Id: 10628
Gene Symbol: TXNIP
TXNIP
0.010 Biomarker disease BEFREE The chronic accumulation of inflammatory mediator in neuronal cells facilitates interactions of TXNIP-nucleotide binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) and NLRP3-ASC, which increases β-amyloid () secretion. 29634349 2019
Entrez Id: 7432
Gene Symbol: VIP
VIP
0.010 AlteredExpression disease BEFREE Chronic VIP administration in 5xFAD mice significantly decreased the levels of <sub>40</sub> and <sub>42</sub> plaques in the subiculum compared to the saline treated 5xFAD mice. 30498985 2019
Entrez Id: 51150
Gene Symbol: SDF4
SDF4
0.010 Biomarker disease BEFREE Calnuc is a Golgi resident, calcium-binding protein, identified as chaperone protein and is reported to protect the cells against the cytotoxicity caused by amyloidosis and ER stress. 30710272 2019
Entrez Id: 9734
Gene Symbol: HDAC9
HDAC9
0.010 AlteredExpression disease BEFREE Moreover, histone deacetylase inhibitor VPA could attenuate latent accumulation and HDAC activity induced by Pb, which might be by regulating the expression of NEP and IDE epigenetically. 30593950 2019
Entrez Id: 199
Gene Symbol: AIF1
AIF1
0.010 Biomarker disease BEFREE The inflammatory response and Amyloid β (Aβ) plaque load in lean and obese 5XFAD mice untreated or treated with MpHE was evaluated by immunolocalization (Iba-1 and GFAP) and RT-qPCR (TNF) assays and thioflavin-S staining, respectively. 31291963 2019
Entrez Id: 3984
Gene Symbol: LIMK1
LIMK1
0.010 Biomarker disease BEFREE Our data suggest that therapeutically targeting LIMK1 may provide dendritic spine resilience to and therefore may benefit cognitively normal patients that are at high risk for developing dementia. 31239325 2019
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.010 Biomarker disease BEFREE The aim of the present study was to explore whether berberine (BBR) activates LKB1/AMPK signaling and ameliorates pathology. 30873920 2019
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.010 Biomarker disease BEFREE Here, we have shown that NCAM1 peptide constructs carrying polycationic sequences derived from Aβ peptide (KKLVFF) and PrP protein (KKRPKP) significantly promote the S100A9 amyloid self-assembly in a concentration-dependent manner by making transient interactions with individual S100A9 molecules, perturbing its native structure and acting as catalysts. 31194501 2019
Entrez Id: 22871
Gene Symbol: NLGN1
NLGN1
0.010 AlteredExpression disease BEFREE β-Amyloid ()-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. 31311385 2019
Entrez Id: 29904
Gene Symbol: EEF2K
EEF2K
0.010 Biomarker disease BEFREE Genetic reduction of the eEF2 kinase (eEF2K) in 2 AD mouse models suppressed AD-associated eEF2 hyperphosphorylation and improved memory deficits and hippocampal long-term potentiation (LTP) impairments without altering brain amyloid β () pathology. 30667373 2019
Entrez Id: 713
Gene Symbol: C1QB
C1QB
0.010 GeneticVariation disease BEFREE Here, we show that absence of TYROBP/DAP12 in a mouse model of AD-type cerebral Aβ amyloidosis (APP<sup>KM670/671NL</sup>/PSEN1<sup>Δexon9</sup>) recapitulates the expected network characteristics by normalizing the transcriptome of APP/PSEN1 mice and repressing the induction of genes involved in the switch from homeostatic microglia to disease-associated microglia (DAM), including Trem2, complement (C1qa, C1qb, C1qc, and Itgax), Clec7a and Cst7. 30283032 2019
Entrez Id: 342096
Gene Symbol: GOLGA6A
GOLGA6A
0.010 Biomarker disease BEFREE GLP-1RA ameliorated metabolic memory-induced amyloid-β and tau pathologies in vivo and in vitro. 30465895 2019