Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
0.020 AlteredExpression disease BEFREE We found that this endocytic receptor conferred protection against amyloid beta-protein toxicity in the presence of activated alpha(2)-macroglobulin and its down-regulation via inhibition by receptor-associated protein or transfection of cells with presenilin 1, increased susceptibility to amyloid beta-protein toxicity. 10899157 2000
Entrez Id: 2
Gene Symbol: A2M
A2M
0.020 GeneticVariation disease LHGDN Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. 18382889 2008
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 Biomarker disease BEFREE We suggest that activation of LXRα and its target gene ABCA1 exerts potent anti-inflammatory effect on the -treated retina. 28760679 2017
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.010 Biomarker disease BEFREE This colloidal formulation of QU-encapsulated LS grafted with RMP-7 and Lf (RMP-7-Lf-QU-LS) was used to traverse human brain microvascular endothelial cells (HBMECs) regulated by human astrocytes (HAs) and to treat SK-N-MC cells after an insult with cytotoxic β-amyloid () fibrils. 28435263 2017
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.050 Biomarker disease BEFREE Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease. 23467355 2013
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.050 GeneticVariation disease BEFREE High deposition was associated significantly with a lower Mini-Mental State Examination score (<27 points, p = 0.04), high systolic blood pressure (p = 0.04), carrying the apolipoprotein E epsilon 4 allele (p < 0.01), and lower plasma ApoE levels (p = 0.02), and variation in the ABCA7 (p = 0.02) and EPHA1 genes (p = 0.02). 24199960 2014
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.050 GeneticVariation disease BEFREE We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of β-amyloid () and parameters of metabolic and cardiovascular health in a population-based cohort of healthy middle-aged and elderly men. 28556232 2017
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.050 Biomarker disease BEFREE ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. 27030769 2016
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
0.050 Biomarker disease BEFREE In consistence with human genetic studies, increasing evidence has demonstrated that ABCA7 deficiency exacerbates pathology using in vitro and in vivo models. 29401741 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE Furthermore, these plant metabolites improved the lysosomal autophagy process by increasing the expression levels of Beclin-1, LC3II and cathepsin B genes for clearance of and NFT, and increased the expression of transporter proteins, P-glycoprotein (P-gp) and low density lipoprotein receptor-related protein-1 (LRP-1) for the clearance of load from brain across the blood-brain barrier (BBB) as well as increased the expression of PPAR-γ and ApoE proteins for clearance of in ApoE mediated pathway from brain. 30877973 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE The expulsion of via the blood-brain barrier is mediated by specialized transport proteins such as P-glycoprotein (P-gp, ABCB1/MDR1). 27915995 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE Restoration of Pgp at the BBB enhances the elimination of the from brain alongside and inhibits the apical to basolateral movement of from the circulatory blood. 25213397 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE P-glycoprotein (P-gp, ABCB1) is an efflux transporter at the blood-brain barrier (BBB), which mediates clearance of beta-amyloid () from brain into blood. 30354871 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 Biomarker disease BEFREE This suggests therefore that LiCl is unlikely to affect the BBB efflux of or other P-gp substrates at pharmacologically-relevant concentrations, suggesting that the -lowering effects of LiCl are unrelated to elevated BBB P-gp expression. 28093288 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.060 GeneticVariation disease BEFREE In this study, we investigated a possible association between 2 common ABCB1 polymorphisms, G2677T/A (Ala893Ser/Thr) and C3435T, AD, and cerebrospinal fluid (CSF) levels of . 21478475 2011
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.040 Biomarker disease BEFREE Recently, we demonstrated that Acetylcholine (ACh) is neuroprotective against the toxic effects of in the cholinergic LAN-2 cells. 28993924 2018
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.040 Biomarker disease BEFREE Here, we have shown that NCAM1 peptide constructs carrying polycationic sequences derived from Aβ peptide (KKLVFF) and PrP protein (KKRPKP) significantly promote the S100A9 amyloid self-assembly in a concentration-dependent manner by making transient interactions with individual S100A9 molecules, perturbing its native structure and acting as catalysts. 31194501 2019
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.040 Biomarker disease BEFREE ABC transporters were shown to be the most important exporter superfamily for toxic peptides, e.g.β-amyloid and α-synuclein. 24012632 2013
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.040 Biomarker disease BEFREE Amyloid-beta Interactions with ABC Transporters and Resistance Modifiers. 29848690 2018
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.010 Biomarker disease BEFREE Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. 21881209 2011
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.010 Biomarker disease BEFREE ABCC6 deficiency may have increased the severity of amyloidosis by increasing the deposition in target tissues of heparan sulphate, which colocalizes spatially and temporally with amyloid proteins, and/or by decreasing the therapeutic activity of colchicine. 16704654 2006
Entrez Id: 9619
Gene Symbol: ABCG1
ABCG1
0.020 Biomarker disease BEFREE ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production. 27196068 2016
Entrez Id: 9619
Gene Symbol: ABCG1
ABCG1
0.020 Biomarker disease BEFREE The highest degree of difference between the two groups was shown by the ATP-binding cassette G1 (Abcg1) which plays a crucial role in cholesterol metabolism and suppresses accumulation. 29468564 2018
Entrez Id: 64137
Gene Symbol: ABCG4
ABCG4
0.010 Biomarker disease BEFREE ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production. 27196068 2016
Entrez Id: 10152
Gene Symbol: ABI2
ABI2
0.010 GeneticVariation disease BEFREE By screening a peptoid library using surface plasmon resonance imaging, amyloid inhibitory peptoid 1 (AIP1) that has high affinity to Aβ42 is identified. 27714968 2017