Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE These results highlight the importance of a thorough evaluation of the GI function in patients with ATTR amyloidosis and should stimulate further studies on the phenotypic differences related to genotype and geographic origin. 31826067 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE Diagnosis and treatment of urinary and sexual dysfunction in hereditary TTR amyloidosis. 31452024 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE In conclusion, we provide novel insights regarding the molecular basis of ATTRm and ATTRwt based on large-scale cohort, expanding our understanding of the phenotypic spectrum associated with TTR gene variation. 31659433 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE As previously seen for ATTR amyloidosis patients with mainly cardiomyopathy, the amyloid fibrils consisted of a mixture of full-length and fragmented TTR species. 31169435 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Inotersen for the treatment of adults with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis. 31268366 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE The Japanese Ministry of Health, Labour and Welfare approved tafamidis (Vyndaqel<sup>®</sup>, Pfizer Inc.) for the treatment of cardiomyopathy caused by both wild-type and mutated transthyretin-derived amyloidoses. 31735731 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Systemic amyloid deposition of aggregated transthyretin causes hereditary and sporadic amyloidoses. 30733338 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE TTR is a protein biomarker related to diverse types of amyloidosis, such as familial amyloidotic polyneuropathy type I (FAP-I), which is the most common hereditary systemic amyloidosis. 30847784 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE <b>Introduction</b>: Hereditary transthyretin-mediated amyloidosis (ATTRv; v for variant) is a rare, progressive, fatal multi-systemic disease, autosomal dominantly inherited with heterogeneous clinical phenotype caused by mutations in the <i>TTR</i> gene. 31566422 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE The effects of curcumin on ATTR amyloidosis will be reviewed and discussed in the current work in order to contribute to knowledge of the molecular mechanisms involved in TTR amyloidosis and propose more efficient drugs for therapy. 30875761 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Human transthyretin (TTR) is implicated in several fatal forms of amyloidosis. 30804345 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE ATTR amyloidosis may be associated with abnormal metabolism of wild-type transthyretin (previously called senile systemic amyloidosis) or with hereditary variants in the transthyretin gene. 31452023 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE These results indicate that dendrimer (G2) may possess both inhibitory and breaking effects on ATTR V30M amyloid, suggesting that dendrimer has the potential as a dual effective agents against TTR amyloidosis. 30912637 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE Here, we present a 2.97 Å cryo electron microscopy structure of a fibril purified from the tissue of a patient with hereditary Val30Met ATTR amyloidosis. 31676763 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Patients diagnosed with light-chain amyloidosis has a poor prognosis compared with transthyretin-related amyloidosis, while no difference was proved in prognostic analysis between wild-type and mutated TTR amyloidosis. 30742933 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Hereditary amyloidogenic transthyretin (ATTRv) amyloidosis with polyneuropathy (also known as familial amyloid polyneuropathy) is a condition with adult onset caused by mutation of transthyretin (TTR) and characterized by extracellular deposition of amyloid and destruction of the somatic and autonomic PNS, leading to loss of autonomy and death. 31209302 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis. 30586695 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. 31728576 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE We evaluated 90 consecutive patients with ATTRm amyloidosis at Kumamoto University. 30284755 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Familial amyloid polyneuropathy (FAP) or ATTRv (amyloid TTR variant) amyloidosis is a fatal hereditary disease characterized by the deposition of amyloid fibrils composed of transthyretin (TTR). 31253122 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 GeneticVariation disease BEFREE Tafamidis meglumine, a transthyretin (TTR) stabilizer, is effective in delaying the progression of neuropathy in TTR amyloidosis with Val30Met mutations. 30478886 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE The two more common forms are immunoglobulin light-chain amyloidosis and transthyretin-related amyloidosis with different prognoses and treatments. 31845305 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE The inherent amyloidogenic potentialof wild type transthyretin (TTR) is enhanced by a large number of point mutations, which destabilize the TTR tetramer, thereby promoting its disassembly and pathological aggregation responsible for TTR-related amyloidosis. 31473362 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE These developments have resulted in last year's approval of the first siRNA therapeutic, called Onpattro (patisiran), for treatment of hereditary amyloidogenic transthyretin (TTR) amyloidosis. 31397996 2019
Entrez Id: 7276
Gene Symbol: TTR
TTR
0.500 Biomarker disease BEFREE Since the phenotype of ATTR amyloidosis varies depending on its penetration rate, it is crucial to always keep in mind the possibility of hereditary ATTR amyloidosis even in the case of amyloidosis with no clear family history. 31666456 2019