Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-β<sub>1-42</sub> in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway.
(intraperitoneal) administration of VA (30 mg/kg, for 3 weeks) after Aβ<sub>1-42</sub>-injection enhanced glutathione levels (GSH) and abrogated ROS generation accompanied by an induction of the endogenous nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) via the activation of Akt and glycogen synthase kinase 3β (GSK-3β) in the brain mice.