Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE These plant metabolites have been shown to ameliorate AD by increasing the expression of insulin degrading enzyme (IDE), neprilysin (NEP), PPAR-γ, and α-secretase, and decreasing the expression of β-secretase (BACE-1) to reduce the levels of oligomers (<sub>O</sub>) deposition in brain neurons. 30877973 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE These results are discussed in terms of the relevance of <sub>4-9</sub>, a major Cu(II) binding fragment generated by neprilysin, as a possible Cu(II) carrier in the brain. 30582328 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Moreover, SRE feeding prevented elevation of the amyloid-β42 level while improving the gene expression of neprilysin and decreasing beta-site APP-cleaving enzyme 1 in the brain. 30295144 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Membrane metalloendopeptidase (MME) and insulin-degrading enzyme (IDE) are two types of proteases that could cleave beta-amyloid () peptides generated by neuron cells of AD patients. 31151136 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE The data obtained allowed us to conclude that the decrease in the activity of the amyloid-degrading enzyme NEP, as well as a reduction in the number of labile interneuronal contacts in the hippocampus, contribute to early cognitive deficits caused by prenatal hypoxia and that there are therapeutic avenues to restore these deficits via NEP activation which could also be used for designing preventive strategies in AD. 31006092 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Overall, our results suggest sustained reduction of NEP and IDE expression in response to Pb sensitizes recovery SH-SY5Y cells to accumulation; however, administration of VPA is demonstrated to be beneficial in modulating clearance. 30593950 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE In the triple transgenic AD mouse model (3xTg-AD), repeated administration of 3 and 10 mg/kg of RGFP-966 reverses pathological tau phosphorylation at Thr<sup>181</sup>, Ser<sup>202</sup>, and Ser<sup>396</sup>, increases levels of the degrading enzyme Neprilysin in plasma, decreases <sub>1-42</sub> protein levels in the brain and periphery, and improves spatial learning and memory. 30397132 2018
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE This provides <sub>4-9</sub> with the potential to act as a Cu<sup>2+</sup> carrier and to mediate its own production by preventing NEP inhibition. 29774745 2018
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE The overexpression of PGRN was also found to increase activity of neprilysin, a key amyloid beta degrading enzyme. 28837568 2017
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE In the present study, we measured plasma levels of amyloid-β1-42(0.142±0.029μg/L)and furin(2.292±1.54μg/L), together with those of the metalloproteinases, insulin-degrading enzyme(1.459±1.14μg/L) and neprilysin(0.073±0.015μg/L), in order to develop biomarkers for AD. 28719622 2017
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE N-terminally truncated amyloid-β42 accumulation showed significant regional association with BACE1 and neprilysin, but not PSD95 that regionally associated with full-length amyloid-β42 accumulation. 29161341 2017
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease BEFREE The MME gene encodes neprilysin (NEP), which is well known to be one of the most prominent beta-amyloid ()-degrading enzymes. 26991897 2016
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE We have now extended our work and shown that, unlike NEP, another amyloid-degrading enzyme, IDE, is not related to over-expression of APP695 in neuroblastoma SH-SY5Y cells but is up-regulated by APP751 and APP770 isoforms independently of AICD but correlating with reduced HDAC1 binding to its promoter. 26376806 2016
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease BEFREE Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid () degradation enzyme neprilysin (NEP) in primary neurons. 24289518 2014
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Presently, co-culture of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) with BV2 microglia under amyloid-β42 (Aβ42) exposure induced a reduction of Aβ42 in the medium as well as an overexpression of the Aβ-degrading enzyme neprilysin (NEP) in microglia. 22015609 2012
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE The decrease in neprilysin leads to a metabolic Aβ imbalance, which can induce the amyloidosis underlying Alzheimer disease. 22767595 2012
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE An alternative model of amyloidosis utilizes intracerebroventricular infusion of thiorphan or phosphoramidon to block the activity of key Aβ degrading enzymes (NEP, NEP2) resulting in accumulation of Aβ. 20941644 2011
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Correlation analyses suggested that NEP expression was correlated with accumulation and clinical diagnosis, being lower in AD than in no cognitive impairment. 20663017 2010
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE In addition, peripheral neprilysin expression reduced amyloid-dependent performance deficits as measured by the Morris water maze. 19021293 2009
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Neprilysin (NEP) is one of the rate-limiting Abeta-degrading enzymes, and its enhancement ameliorates extracellular amyloid pathology, synaptic dysfunction, and memory defects in mouse models of Abeta amyloidosis. 18463098 2008
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE In vivo, DSP4-treatment decreased expression and activity of the Abeta degrading enzyme neprilysin, while in vitro NA increased phagocytosis of Abeta1-42 by microglia. 16837104 2007
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease LHGDN These data further support a role for neprilysin in regulating cerebral amyloid deposition and suggest that gene transfer approaches might have potential for the development of alternative therapies for Alzheimer's disease. 12657655 2003