| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | We also find that neuronal over-expression of CAST in hSOD1(G93A) transgenic mice inhibited production of putative neurotoxic caspase-cleaved tau and activation of Cdk5, which have been implicated in neurodegeneration in ALS models, and also reduced the formation of SOD1 oligomers. | 26756888 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Similar transport defects observed in neurons from a mouse model of amyotrophic lateral sclerosis are rescued by CDK5 inhibition. | 26166569 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown to contribute to the pathogenesis in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD). | 22262900 | 2012 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model. | 18397603 | 2008 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | One gene in the candidate interval, CDK5, was selected for immediate mutation analysis based upon its known association with an ALS-like phenotype in mice however, no mutations were identified. | 17354000 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | Importantly, increasing evidence has linked Cdk5 to the etiopathology of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. | 15135890 | 2004 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results indicate that a cell cycle signaling at the neuronal G1-S checkpoint subsequent to Cdk5 deregulation may constitute a critical step of the neuronal death pathway in ALS caused by mutant SOD1. | 12657672 | 2003 | ||||
|
0.080 | Biomarker | disease | BEFREE | These observations suggest a role for cdk-5 in the pathogenesis of ALS. | 9596352 | 1998 |