Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 Biomarker disease BEFREE Recently, it has been demonstrated this collaboration also takes place during fibrotic diseases, where TGF-β1 activates the WNT/β-catenin pathway that results in dedifferentiation of fibroblasts into myofibroblasts, increased production of extracellular matrix components and fibrosis. 30632705 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 Biomarker disease BEFREE Inhibition of TGF-β1 receptor kinase in HF MyoFb promotes dedifferentiation of MyoFb with loss of α-smooth muscle actin and depolymerization of stress fibers, and reduces the expression of profibrotic genes and cytokines levels to non-HF levels. 31072570 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 Biomarker disease BEFREE Taken together, these results suggest that TGF-β1 may be involved in epithelial cell dedifferentiation, growth arrest and apoptosis in feline CKD as in human disease, and that cats may be a useful, naturally occurring model of human CKD. 30138414 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 Biomarker disease BEFREE Using the six-well plate approach, cells were treated with SB431542 (an inhibitor of TGF-β receptor ALK5) or human TGF-β1 during dedifferentiation. 28781950 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 AlteredExpression disease BEFREE Further results suggested that miR-210 promoted the expression of TGF-β1 and its downstream effectors Snail1 and Slug which were highly elevated in the process of OS dedifferentiation. 28032372 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 AlteredExpression disease BEFREE Hepatocyte-specific basigin/CD147-knockout mice decreased the susceptibility to N-nitrosodiethylamine-induced tumorigenesis by suppressing TGF-β1-CD147 signaling and inhibiting dedifferentiation in hepatocytes during tumor progression. 27041581 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 Biomarker disease BEFREE Here, we show that expression of the transcription factor Basonuclin-1 (Bnc1) modulates TGF-β1-induced epithelial dedifferentiation of mammary epithelial cells. 24662832 2015
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.080 AlteredExpression disease BEFREE In rats with renal mass reduction, protein accumulation in podocytes as a consequence of enhanced transcapillary passage preceded podocyte dedifferentiation and injury, increase in TGF-beta1 expression in podocytes, and TGF-beta1-dependent activation of mesangial cells. 12466133 2002