HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*1501 is the main subtype of HLA-DR2, and may be the susceptibility gene of AA.
|
10905054 |
2000 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Although both DRB1( *)1501 and DRB1( *)1502 contribute to the development of AA, the methods of contribution differ between the two alleles.
|
17198869 |
2007 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although DRB1*03 percent frequency was significantly higher in controls 0.175 (p = 0.023) with odds ratio = 0.514, as compared to patients 0.106.Therefore DRB1*15 emerged as a susceptible allele and DRB1*03 as a protective allele in Pakistani Aplastic anemia patients and control samples.
|
19860590 |
2009 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
But, other sites of HLA-A/B/DRB1 in our study had no correlations with AA (all P<sub>c</sub> > 0.05).
|
28902578 |
2018 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, it has been reported that most patients with AA and refractory anemia (RA) who carry HLA-DRB1*15 and show a good response to immunosuppressive therapies have an expanded population of GPI-deficient clones.
|
12627844 |
2003 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic construct of HLA DRB1 was studied in Iranian normal populations and patients with aplastic anaemia and Fanconi's disease.
|
19046304 |
2008 |
HLA-DRB1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HLA-B*51:01, DRB1*03:01 and DRB1*11:01 are expressed at low levels in children with AA.
|
22572536 |
2012 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
LHGDN |
In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease.
|
18571007 |
2008 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease.
|
18571007 |
2008 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed a positive association of the DRB1(∗)15 allele in Mexican patients with aplastic anemia, which coincides with that reported internationally.
|
22580214 |
2012 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The high frequency of HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype in PNH, including AA-PNH syndrome, and AA patients suggests that linkage exists between the disorders and that immune mechanisms in an HLA-restricted manner play an important role in the pathogenesis of these disorders.
|
12070003 |
2002 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The high frequency of HLA-DRB1*15 in the Kadazan and Dusun population combined with the wide variety of environmental factors associated with aplastic anemia could be the reason for the elevated incidence of aplastic anemia in the Kadazan and Dusun in Sabah.
|
21762745 |
2011 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis suggested that HLA-DRB1*15 and HLA-DRB1*15:01 polymorphisms might be associated with increased AA risk in Asians.
|
27611583 |
2016 |
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the CyA-dependent response of AA is closely related to an HLA class II haplotype of DRB1*1501-DQA1*0102-DQB1*0602 and suggest that, in AA patients with this haplotype, immune mechanisms play an important role in the pathogenesis of bone marrow failure.
|
7994040 |
1994 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that the AA patient has T cells capable of killing hematopoietic cells in an HLA-DRB1*0405-restricted manner and that such cytotoxic T cells may contribute to the pathogenesis of AA.
|
9160674 |
1997 |
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether this DRB1 allele can also predict a response to antithymocyte globulin (ATG) therapy in AA patients, we analysed the results of HLA-DRB1 typing in 59 Japanese patients who received ATG within 2 years after diagnosis of AA and also in 52 patients treated with CyA.
|
8562389 |
1996 |