Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE But, other sites of HLA-A/B/DRB1 in our study had no correlations with AA (all P<sub>c</sub> > 0.05). 28902578 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE The meta-analysis suggested that HLA-DRB1*15 and HLA-DRB1*15:01 polymorphisms might be associated with increased AA risk in Asians. 27611583 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 AlteredExpression disease BEFREE HLA-B*51:01, DRB1*03:01 and DRB1*11:01 are expressed at low levels in children with AA. 22572536 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE Our results showed a positive association of the DRB1(∗)15 allele in Mexican patients with aplastic anemia, which coincides with that reported internationally. 22580214 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE The high frequency of HLA-DRB1*15 in the Kadazan and Dusun population combined with the wide variety of environmental factors associated with aplastic anemia could be the reason for the elevated incidence of aplastic anemia in the Kadazan and Dusun in Sabah. 21762745 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE Although DRB1*03 percent frequency was significantly higher in controls 0.175 (p = 0.023) with odds ratio = 0.514, as compared to patients 0.106.Therefore DRB1*15 emerged as a susceptible allele and DRB1*03 as a protective allele in Pakistani Aplastic anemia patients and control samples. 19860590 2009
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease LHGDN In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease. 18571007 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE Genetic construct of HLA DRB1 was studied in Iranian normal populations and patients with aplastic anaemia and Fanconi's disease. 19046304 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease. 18571007 2008
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease LHGDN Although both DRB1( *)1501 and DRB1( *)1502 contribute to the development of AA, the methods of contribution differ between the two alleles. 17198869 2007
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE Furthermore, it has been reported that most patients with AA and refractory anemia (RA) who carry HLA-DRB1*15 and show a good response to immunosuppressive therapies have an expanded population of GPI-deficient clones. 12627844 2003
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease LHGDN The high frequency of HLA-DRB1*1501-DQA1*0102-DQB1*0602 haplotype in PNH, including AA-PNH syndrome, and AA patients suggests that linkage exists between the disorders and that immune mechanisms in an HLA-restricted manner play an important role in the pathogenesis of these disorders. 12070003 2002
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE HLA-DRB1*1501 is the main subtype of HLA-DR2, and may be the susceptibility gene of AA. 10905054 2000
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE These results indicate that the AA patient has T cells capable of killing hematopoietic cells in an HLA-DRB1*0405-restricted manner and that such cytotoxic T cells may contribute to the pathogenesis of AA. 9160674 1997
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE To determine whether this DRB1 allele can also predict a response to antithymocyte globulin (ATG) therapy in AA patients, we analysed the results of HLA-DRB1 typing in 59 Japanese patients who received ATG within 2 years after diagnosis of AA and also in 52 patients treated with CyA. 8562389 1996
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE These findings indicate that the CyA-dependent response of AA is closely related to an HLA class II haplotype of DRB1*1501-DQA1*0102-DQB1*0602 and suggest that, in AA patients with this haplotype, immune mechanisms play an important role in the pathogenesis of bone marrow failure. 7994040 1994