Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE Pharmacological and knock-down experiments show that the retinoic acid (RA) signaling promotes differentiation of oligodendrocyte precursor cells (OPCs) and remyelination in a cross talk between neuronal RA receptor-beta (RARβ) and RARα in NG2<sup>+</sup> cells. 30760627 2019
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE Retinoic acid (RA) signaling through its receptors (RARA, RARB, RARG, and the retinoic X receptor RXRA) is essential for healthy placental and fetal development. 29246089 2018
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 AlteredExpression disease BEFREE Additionally, LPS-induced autophagy further reduced retinoic acid (RA) signaling, as demonstrated by a decrease in the intracellular RA level and Rar target genes, resulting in the downregulation of Bambi and promoting the sensitization of the HSC's fibrosis response to TGFB. 29160747 2017
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE RA treatment-induced increase in RARα, Src and NR1 expressions in mVAD neurons was much lower than that in VAN neurons. 28570942 2017
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE Acute promyelocytic leukemia (APL) cases expressing the t(15,17) product, promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha), have clinical remissions through leukemic cell differentiation after all-trans-retinoic acid (RA) treatment. 14976209 2004
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE Two features are unique to this leukemia: its remission after retinoic acid (RA) treatment through induction of blast differentiation, and the presence in the leukemic blast of fusion proteins in which the retinoic acid receptor alpha (RARalpha) fuses to distinct partners. 11561158 2001
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 Biomarker disease BEFREE APLs with PML-RARalpha or PLZF-RARalpha fusion protein differ only in their response to retinoic acid (RA) treatment: the t(15;17) (PML-RARalpha-positive) APL blasts are sensitive to RA in vitro, and patients enter disease remission after RA treatment, while those with t(11;17) (PLZF-RARalpha-positive) APLs do not. 10373566 1999
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 GeneticVariation disease BEFREE Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (RARA) and the PML gene, is sensitive to retinoic acid (RA) treatment, while APL patients harbouring translocations between RARA and the PLZF gene do not respond to RA. 9462740 1998
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 AlteredExpression disease BEFREE Clinical remissions induced with all-trans retinoic acid (RA) treatment in acute promyelocytic leukemia are linked to PML/RARalpha expression in leukemic cells. 8755574 1996
Entrez Id: 5914
Gene Symbol: RARA
RARA
0.100 AlteredExpression disease BEFREE Interestingly, retinoic acid (RA) treatment suppresses the differentiation blockade induced by high level PML-RAR alpha protein; indeed, Zn(2+)-treated MTPR9 cells incubated with RA plus D3 exhibited significant terminal monocytic maturation, comparable to that of cells treated with D3 alone or combined with RA in absence of Zn2+. 7519122 1994